Mitochondrial 2-oxoglutarate/malate carrier protein

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.^[5][6][7] Inactivating mutations in this gene predispose to metastasic paraganglioma.^[8]

SLC25A11
Identifiers
Aliases	SLC25A11, OGC, SLC20A4, solute carrier family 25 member 11, PGL6
External IDs	OMIM: 604165; MGI: 1915113; HomoloGene: 2637; GeneCards: SLC25A11; OMA:SLC25A11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,937,130 bp[1] End 4,940,053 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 43.21 cM Start 70,535,022 bp[2] End 70,538,305 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh right auricle left ventricle gastrocnemius muscle body of tongue mucosa of transverse colon right frontal lobe prefrontal cortex Skeletal muscle tissue of rectus abdominis Top expressed in extraocular muscle right ventricle interventricular septum digastric muscle myocardium of ventricle plantaris muscle cardiac muscle tissue of left ventricle temporal muscle muscle of thigh sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding oxoglutarate:malate antiporter activity transmembrane transporter activity Cellular component integral component of membrane integral component of plasma membrane membrane mitochondrion nucleus mitochondrial inner membrane Biological process gluconeogenesis alpha-ketoglutarate transport mitochondrial transport transport transmembrane transport malate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8402 67863 Ensembl ENSG00000108528 ENSMUSG00000014606 UniProt Q02978 Q9CR62 RefSeq (mRNA) NM_003562 NM_001165417 NM_001165418 NM_024211 RefSeq (protein) NP_001158889 NP_001158890 NP_003553 NP_077173 Location (UCSC) Chr 17: 4.94 – 4.94 Mb Chr 11: 70.54 – 70.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000108528 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014606 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F (Mar 1999). "Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3". Cytogenet Cell Genet. 83 (3–4): 256–7. doi:10.1159/000015198. PMID 10072597. S2CID 36221506.
6. Iacobazzi V, Palmieri F, Runswick MJ, Walker JE (Jan 1993). "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier". DNA Seq. 3 (2): 79–88. doi:10.3109/10425179209034000. PMID 1457818.
7. "Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11".
8. Buffet A, Morin A, Castro-Vega LJ, Habarou F, Lussey-Lepoutre C, Letouzé E, Lefebvre H, Guilhem I, Magalie H (2018-02-05). "Germline mutations in the mitochondrial 2-oxoglutarate/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas". Cancer Research. 78 (8): 1914–1922. doi:10.1158/0008-5472.CAN-17-2463. ISSN 1538-7445. PMID 29431636.

Further reading

• Bisaccia F, Zara V, Capobianco L, et al. (1996). "The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier". Biochim. Biophys. Acta. 1292 (2): 281–88. doi:10.1016/0167-4838(95)00215-4. PMID 8597574.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bisaccia F, Capobianco L, Mazzeo M, Palmieri F (1996). "The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224". FEBS Lett. 392 (1): 54–8. doi:10.1016/0014-5793(96)00784-3. PMID 8769314. S2CID 46276462.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Palmisano A, Zara V, Hönlinger A, et al. (1998). "Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane". Biochem. J. 333 ( Pt 1) (Pt 1): 151–8. doi:10.1042/bj3330151. PMC 1219567. PMID 9639574.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Coll O, Colell A, García-Ruiz C, et al. (2003). "Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion". Hepatology. 38 (3): 692–702. doi:10.1053/jhep.2003.50351. hdl:10261/111821. PMID 12939596. S2CID 2128549.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kabe Y, Ohmori M, Shinouchi K, et al. (2006). "Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier". J. Biol. Chem. 281 (42): 31729–35. doi:10.1074/jbc.M604729200. PMID 16920706.