Michael Smith or Mike Smith may refer to:
Music
- Michael Joseph Smith (born 1938), American classical composer and pianist
- Michael Peter Smith (1941–2020), American songwriter and performer
- Michael S. Smith (drummer) (1946–2006), American jazz drummer
- Michael W. Smith (born 1957), American Christian singer and musician
- Michael L. Smith (born 1953), known as Michael Lovesmith, American R&B musician, producer and executive
- Mike Smith (jazz saxophonist) (born 1957), American jazz saxophonist
- Mike Smith (singer-songwriter) (born 1939), American singer-songwriter
- Mike Smith (Paul Revere & the Raiders) (born 1942), American drummer best known as a member of Paul Revere & the Raiders
- Mike Smith (Dave Clark Five) (1943–2008), English singer-songwriter
- Mike Smith (drummer) (born 1970), American drummer for Suffocation
- Mike Smith (guitarist) (born 1973), American guitarist for Limp Bizkit
- Mike Smith (record producer), Cuban American record producer and musician
- Mike Smith (saxophonist), English saxophonist for The Ailerons
- Mike Smith (born 1947), Welsh saxophonist (Amen Corner)
Other entertainment
- M. G. Smith (Michael G. Smith, 1921–1993), Jamaican poet and social anthropologist
- Michael Smith (poet) (1942–2014), Irish poet and translator
- Michael Smith (author) (born 1946), British author and journalist
- Mikey Smith (1954–1983), Jamaican dub poet and performance artist
- Michael Marshall Smith (born 1965), English novelist and screenwriter
- Michael Smith (chef) (born 1966), American born celebrity chef residing in Canada
- Michael V. Smith, Canadian novelist, poet and filmmaker
- Michael Farris Smith, American writer
- Mike Prestwood Smith, sound mixer
- Mike Smith (music executive), managing director of Columbia Records UK
- Michael Smith (diplomat) (1936–2021), American diplomat and trade negotiator
- Michael Hoke Smith (1855–1931), American politician
- Michael Smith (Irish politician) (born 1940), Irish politician
- Carl Michael Smith (born 1944), known as Mike, former Oklahoma Secretary of Energy
- Mike Smith (Louisiana politician) (born 1948), former Louisiana state senator, member of the Long family
- Michael F. Smith, member of the Delaware House of Representatives
- Michael Keith Smith (1953–2010), chairman of United Kingdom pressure group, the Conservative Democratic Alliance
- Michael K. Smith (Illinois politician) (1966–2014), former member of the Illinois House of Representatives
- Michael K. Smith (Vermont official), secretary of human services for the state of Vermont, 2006–2008
- Mike Smith (Nova Scotia politician), mayor of Colchester County, Nova Scotia, Canada
- Michael Adye Smith (1886–1965), Australian politician
- Michael Smith (Georgia politician) (born 1983), member of the Georgia House of Representatives
Basketball
- Mike Smith (basketball, born 1963), former professional basketball player from the University of South Carolina-Spartanburg
- Michael Smith (basketball, born 1965), former BYU and Boston Celtics player, and former Los Angeles Clippers television and radio commentator
- Michael Smith (basketball, born 1972), former NBA player from Washington, D.C.
- Mike Smith (basketball, born 1976), professional basketball player from West Monroe, Louisiana
- Mike Smith (basketball, born 1987), professional basketball player from East Tennessee State University
- Mike Smith (basketball, born 1997), college basketball player for the Michigan Wolverines
Other sports
- Michael Smith (Australian footballer) (born 1959), Australian rules footballer
- Michael Smith (rugby league, born c. 1947), in the 1960s, and 1970s for Featherstone Rovers and Huddersfield
- Mike Smith (rugby league), in the 1970s, and 1980s for Great Britain and Hull Kingston Rovers
- Michael Smith (rugby league, born 1976), in the 1990s and 2000s for North Harbour, New Zealand, Canterbury Bulldogs
- Michael Smith (rugby union) (born 1998), Canadian rugby union player
- Michael Smith (ice hockey) (born 1971), Canadian ice hockey defenseman
- Mike Smith (ice hockey, born 1945), general manager for Winnipeg Jets and Chicago Blackhawks
- Mike Smith (ice hockey, born 1982), Canadian goaltender for the Edmonton Oilers
- Michael Smith (wrestler) (born 1963), American professional wrestler
- Mike E. Smith (born 1965), American jockey
- Mike Smith (decathlete) (born 1967), Canadian decathlete
- Michael Smith (darts player) (born 1990), English darts player
- Michael Smith (canoeist), British slalom canoeist
- Mike Smith (softball), head coach of the California Baptist Lancers softball team
- Mike Smith (running coach) (born 1980), cross country and track and field coach for the Northern Arizona Lumberjacks
- Michael Smith (sprinter), winner of the 2002 4 × 400 meter relay at the NCAA Division I Indoor Track and Field Championships
- Michael Smith (diplomat) (1936–2021), American diplomat and trade negotiator
- Michael Smith (judge) (1740–1809), Irish judge
- Michael Babington Smith (1901–1984), British banker, sportsman, and soldier
- Mike Sharwood Smith (born 1942), linguist
- Michael John Smith (espionage) (born 1948), British Cold War spy
- Michael A. Smith (philosopher) (born 1954), philosopher at Princeton University
- Michael S. Smith (interior designer) (born 1964), American interior designer
- Michael Acton Smith (born 1974), CEO of Mind Candy
- Michael S. Smith II, counter-terrorism advisor to members of the United States Congress
- Michael J. Smith, U.S. army sergeant, dog handler convicted for prisoner abuse at Abu Ghraib prison
- Michael Smith (police officer), police sergeant killed during the 2016 shooting of Dallas police officers
- Michael Smith (aviator) (born 1968), Australian aviator
- Michael Smith (natural gas industry), founder, chairman, and CEO of Freeport LNG
- Michael Daniel Smith (1991–1994), three-year-old boy murdered by his mother Susan Smith