Metis or Métis, meaning "mixed" in French, may refer to:
- Métis, recognized Indigenous communities in Canada and the United States whose distinct culture and language emerged after early intermarriage between First Nations peoples and early European settlers, primarily French fur trappers
- Grand-Métis, Quebec, Canada
- Métis-sur-Mer, Quebec, Canada
- Saint-Paul-des-Métis, now St. Paul, Alberta, Canada
- Metis Shoal, the tip of a submarine volcano in Tonga
- Metiş, a village in Mihăileni, Sibiu, Romania
- Metis Island in Antarctica
- 9 Metis, an asteroid
- 9K115 Metis, a Russian anti–tank missile system
- 9K115-2 Metis-M, a Russian anti–tank missile system
- Metis (American musician) (fl. 21st century), American rapper
- Metis (theorem prover), an automated theorem prover
- Metis (Japanese musician) (born 1984), Japanese reggae singer
- Metis (moon), the innermost and fastest-moving of Jupiter's known moons
- Metis (mythology), an Oceanid and the first wife of Zeus
- Metis (software), business modeling software
- Metis (software), integrated cloud-based system provided by Oracle for Home Office
- METIS, a software package for graph partitioning
- METIS, an instrument planned to be installed in the Extremely Large Telescope
- Metis TransPacific Airlines, a Canadian airline based in Vancouver
- Metis (holothurian), or Actinopyga, a genus of sea cucumbers
- Metis (Character), a playable character from Persona 3 FES