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Chemical compound From Wikipedia, the free encyclopedia
Methisazone (USAN) or metisazone (INN)[1] is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. During trials in the 1960s it showed promising results against smallpox infection, but widespread use was considered logistically impractical in the developing countries facing smallpox cases, and it saw only limited use. In developed countries able to cope with the logistic challenge, treatment of smallpox could be achieved just as effectively with immunoglobulin therapy, without the severe nausea associated with metisazone.[2]
Names | |
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IUPAC name
[(1-Methyl-2-oxoindol-3-ylidene)amino]thiourea | |
Other names
Metisazone | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.016.016 |
EC Number |
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KEGG | |
MeSH | D008720 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C10H10N4OS | |
Molar mass | 234.28 g/mol |
Pharmacology | |
J05AA01 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Methisazone has been described as being used in prophylaxis since at least 1965.[3][4]
The condensation of N-methylisatin with thiosemicarbazide leads to methisazone.[citation needed]
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