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Pecazine
Chemical compound From Wikipedia, the free encyclopedia
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Pecazine (INN), also known as mepazine (trade name Pacatal), is a phenothiazine formerly used as a neuroleptic drug or major tranquilizer.
Pecazine was first synthesized in 1953 by Wilhelm Schuler and Otto Nieschulz and was quickly incorporated into psychiatric practice as an ataractic, i.e., a true tranquilizer rather than a hypnotic or depressant. It was considered interchangeable with chlorpromazine, albeit with a different side effect profile, which included less sedation and a lower risk of extrapyramidal symptoms due to its potent parasympatholytic and anticholinergic effect.[1]
As early as 1958, however, studies reported inferiority to other phenothiazines in the treatment of schizophrenia and questioned its place in the clinic;[2][3] in 1960, a double-blind, randomized controlled trial found pecazine to be no more effective than placebo.[4] Subsequent research found that, like the structurally related promethazine, pecazine is essentially devoid of antipsychotic activity.[5]
Pecazine was implicated in a number of cases of agranulocytosis and was subsequently withdrawn from the market.[6][7][8][9] More recently, it has become a subject of research interest as a MALT1 and RANKL inhibitor.[10][11]
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