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39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.[5]

Quick Facts MRPL22, Available structures ...
MRPL22
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22
External IDsOMIM: 611835; MGI: 1333794; HomoloGene: 56664; GeneCards: MRPL22; OMA:MRPL22 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014180
NM_001014990

NM_175001

RefSeq (protein)

NP_001014990
NP_054899

NP_778166
NP_001390902

Location (UCSC)Chr 5: 154.94 – 154.97 MbChr 11: 58.06 – 58.07 Mb
PubMed search[3][4]
Wikidata
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.[5]

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References

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