Major facilitator superfamily domain-containing protein 9

Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene. It is a potential solute carrier, and called atypical solute carrier^[5] since it is not named according to the SLC nomenclature.^[6] It is expressed both in central and peripheral organs.^[7]

MFSD9
Identifiers
Aliases	MFSD9, major facilitator superfamily domain containing 9
External IDs	MGI: 2443548; HomoloGene: 13100; GeneCards: MFSD9; OMA:MFSD9 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 102,714,630 bp[1] End 102,736,888 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 40,811,198 bp[2] End 40,829,847 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii mucosa of transverse colon body of pancreas rectum paraflocculus of cerebellum jejunal mucosa right lobe of liver bone marrow cells duodenum endothelial cell Top expressed in secondary oocyte jejunum primary oocyte proximal tubule lumbar spinal ganglion right kidney prostate ileum human kidney large intestine More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity Cellular component membrane integral component of membrane Biological process transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84804 211798 Ensembl ENSG00000135953 ENSMUSG00000041945 UniProt Q8NBP5 Q8C0T7 RefSeq (mRNA) NM_032718 NM_001322080 NM_001322081 NM_172499 RefSeq (protein) NP_001309009 NP_001309010 NP_116107 NP_766087 Location (UCSC) Chr 2: 102.71 – 102.74 Mb Chr 1: 40.81 – 40.83 Mb PubMed search [3] [4]
Wikidata
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References

1. GRCh38: Ensembl release 89: ENSG00000135953 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041945 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
6. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
7. Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC 5648162. PMID 29049335.