Perilipin-3

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.^[5] Its gene product, as well as the gene itself, is commonly known as TIP47.

PLIN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SZI
Identifiers
Aliases	PLIN3, M6PRBP1, PP17, TIP47, perilipin 3
External IDs	OMIM: 602702; MGI: 1914155; HomoloGene: 4247; GeneCards: PLIN3; OMA:PLIN3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,838,341 bp[1] End 4,867,694 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,584,476 bp[2] End 56,599,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx body of tongue inferior ganglion of vagus nerve superior surface of tongue nipple jejunal mucosa mucosa of esophagus stromal cell of endometrium pericardium epithelium of esophagus Top expressed in epithelium of small intestine intestinal villus ileum yolk sac jejunum myocardium of ventricle duodenum lacrimal gland utricle right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding Cellular component endosome lipid droplet Golgi apparatus endosome membrane membrane transport vesicle cytoplasm cytosol Biological process vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10226 66905 Ensembl ENSG00000105355 ENSMUSG00000024197 UniProt O60664 Q9DBG5 RefSeq (mRNA) NM_005817 NM_001164189 NM_001164194 NM_025836 RefSeq (protein) NP_001157661 NP_001157666 NP_005808 NP_080112 Location (UCSC) Chr 19: 4.84 – 4.87 Mb Chr 17: 56.58 – 56.6 Mb PubMed search [3] [4]
Wikidata
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Function

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.^[6]

The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,^[7] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.^[8]

TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.^[9]

Interactions

M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.^[10][11]