This is a list of famous or notable people from the Dominican Republic. The list also includes individuals of Dominican ancestry who reside overseas.
- Rafael Alburquerque – former vice president
- Geovanny Vicente – political strategist and CNN columnist
- Pedro Franco Badía – former Secretary of the Interior and Police
- Buenaventura Báez Méndez – former president
- Joaquín Balaguer Ricardo – former president (1960–1962, 1966–1978, 1986–1996)
- Ramón Emeterio Betances – founder of Puerto Rican independence movement (Dominican father)
- Salvador Jorge Blanco – former president (1982–1986)
- Tomás Bobadilla – first ruler of the Dominican Republic
- Juan Bosch y Gaviño – former president
- Francisco Domínguez Brito – lawyer, politician
- Francisco Alberto Caamaño Deñó – former president
- Fernando Cabrera – New York City Councilman
- Ramón Cáceres – former president
- Margarita Cedeño de Fernández – vice-president and former First Lady of the Dominican Republic
- David Collado – former mayor of Santo Domingo
- Ricardo de los Santos Polanco – politician, and President of Senate of the Dominican Republic
- Luis Colón, 1st Duke of Veragua – nobleman, grandson of Christopher Columbus
- Lorraine Cortés-Vázquez – 65th Secretary of State of New York
- Juan Pablo Duarte – one of the founding fathers of the Dominican Republic
- Adriano Espaillat – New York State Assemblyman; first Dominican American to be elected to a State House in the United States
- Rafael Espinal – New York State Assemblyman
- Rafael Estrella Ureña – former president
- Carlos Felipe Morales – former president
- Ruy Fernández de Fuenmayor – Colonial governor of Venezuela
- Leonel Fernández Reyna – former president (1996–2000, 2004–2008, 2008–2012)
- Pedro Florentino – hero of the Battle of Jacuba, during the War of Independence from Haiti
- Maximiliano Gómez – revolutionary political leader
- Máximo Gómez – military commander of the Cuban War of Independence
- Petronila Angélica Gómez – feminist
- Antonio Guzmán Fernández – former president
- Ulises Heureaux – former president
- Antonio Imbert Barrera – former president
- Gregorio Luperón – former president
- Miguel Martinez – former New York City Councilman
- Sabina Matos – lieutenant governor of Rhode Island
- Danilo Medina – former president (2012–2016)
- Lucia Medina – accountant and politician
- Hipólito Mejía – former president
- Ramón Matías Mella – one of the founding fathers of the Dominican Republic
- Fernando Arturo de Meriño – politician, theologian
- The Mirabal sisters – political dissidents
- Adolfo Alejandro Nouel – Santo Domingo archbishop and interim president
- José Nuñez-Melo – Canadian politician
- José Francisco Peña Gómez – mayor of Santo Domingo (1982–1986)
- Joseline Peña-Melnyk – member of the Maryland General Assembly
- Cesar A. Perales – 67th Secretary of State of New York
For a complete list, please refer to List of presidents of the Dominican Republic