Lisinopril/amlodipine
Combination drug used to treat high blood pressure From Wikipedia, the free encyclopedia
Lisinopril/amlodipine, sold under the brand name Lisonorm among others, is a medication used to treat high blood pressure.[1] It is a combination of lisinopril, an ACE inhibitor,with amlodipine, a calcium channel blocker.[1] It may be used when blood pressure is not well controlled with each of the two agents alone.[4] It is taken by mouth.[1]
Lisinopril (top) and amlodipine (bottom) | |
| Combination of | |
|---|---|
| Lisinopril | ACE inhibitor |
| Amlodipine | Calcium channel blocker |
| Clinical data | |
| Trade names | Lisonorm, Dironorm, others |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| (verify) | |
Side effects may include low blood pressure, kidney problems, liver problems, cough, and high blood potassium.[4] It should not be used in people who have previously had angioedema due to ACE inhibitors.[4] Use is not recommended during pregnancy or breastfeeding.[4] Lisinopril works by decreasing angiotensin II and increasing bradykinin while amlodipine decreases the entry of calcium into the muscle cells in the heart and blood cells.[4]
The combination was approved for medical use in the European Union in 2008.[1] The combination on the World Health Organization's List of Essential Medicines.[5][6] While it is available in India and the European Union it is not available in Canada, Australia, or the United States as of 2019.[7]
Pharmacology
Lisinopril/amlodipine is a combination of two agents which both act to induce vascular smooth muscle relaxation to lower blood pressure in distinct ways:[1]
- Lisinopril inhibits angiotensin converting enzyme (ACE), the enzyme responsible for converting angiotensin I into angiotensin II (a vasoconstrictor).
- Amlodipine inhibits influx of calcium into smooth muscle cells through calcium channels thereby inhibiting Ca-dependent contraction.
References
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