Larissa is the capital and largest city of Thessaly, Greece
Larissa or Larisa may also refer to:
Ancient Greek settlements
- Larissa Cremaste, an ancient Greek city in Achaea Phthiotis, in the south east of Thessaly
- Larissa (Argos), the acropolis of the Greek city of Argos in the Peloponnese, Greece
- Larisa (Caria), an ancient Greek town in Caria, Anatolia, now in Turkey
- Larissa (Elis), an ancient Greek city in Elis, Peloponnese
- Larisa (Ionia), an ancient Greek town in Ionia, Anatolia, now in Turkey
- Larisa (Lydia), an ancient Greek town in Lydia, Anatolia, now in Turkey
- Larissa (Thrace), an ancient Greek city in the region between the rivers Nestos and Hebros
- Larisa (Troad), an ancient Greek city in Troad, northwestern Turkey. A Larissa mentioned in Homer's Iliad was likely this city, but some 19th century scholars erroneously placed it in Thrace
- Larissa Phrikonis, an ancient Greek city in Aeolis, western Turkey
- Larissa, an ancient Greek city in Syria settled by colonists from the Thessalian city of the same name, now known as Shaizar
- Larissa, ancient name of Gortyn