Lecithin retinol acyltransferase

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.^[5][6]

LRAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q95
Identifiers
Aliases	LRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), lecithin retinol acyltransferase
External IDs	OMIM: 604863; MGI: 1891259; HomoloGene: 3483; GeneCards: LRAT; OMA:LRAT - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 154,626,945 bp[1] End 154,753,120 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 82,799,886 bp[2] End 82,811,280 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium testicle gonad gallbladder jejunal mucosa C1 segment duodenum right lobe of liver muscle layer of sigmoid colon tibial nerve Top expressed in retinal pigment epithelium median eminence arcuate nucleus epithelium of small intestine right lung right lung lobe Paneth cell ciliary body duodenum migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acyltransferase activity retinol binding O-acyltransferase activity transferase activity retinoic acid binding lecithin:11-cis retinol acyltransferase activity O-palmitoyltransferase activity phosphatidylcholine-retinol O-acyltransferase activity Cellular component endoplasmic reticulum cytoplasm endosome integral component of membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane multivesicular body rough endoplasmic reticulum perinuclear region of cytoplasm Biological process vitamin A metabolic process visual perception retinoid metabolic process response to stimulus positive regulation of lipid transport cellular response to leukemia inhibitory factor retinol metabolic process response to retinoic acid response to vitamin A response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9227 79235 Ensembl ENSG00000121207 ENSMUSG00000028003 UniProt O95237 Q9JI60 RefSeq (mRNA) NM_001301645 NM_004744 NM_023624 RefSeq (protein) NP_001288574 NP_004735 NP_076113 Location (UCSC) Chr 4: 154.63 – 154.75 Mb Chr 3: 82.8 – 82.81 Mb PubMed search [3] [4]
Wikidata
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Function

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance

Mutations in this gene have been associated with early-onset severe retinal dystrophy.^[6]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.^[7]

See also

• Visual cycle