Laminin, alpha 5

Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene.^[5][6]

LAMA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y38
Identifiers
Aliases	LAMA5, Laminin, alpha 5, laminin subunit alpha 5
External IDs	OMIM: 601033; MGI: 105382; HomoloGene: 4060; GeneCards: LAMA5; OMA:LAMA5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 62,307,955 bp[1] End 62,367,312 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 102.7 cM Start 179,818,166 bp[2] End 179,867,652 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum right lung right coronary artery popliteal artery tibial arteries muscle layer of sigmoid colon gastric mucosa upper lobe of left lung skin of abdomen Top expressed in gastrula decidua ascending aorta medullary collecting duct left lung lobe epiblast blastocyst molar aortic valve islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity integrin binding signaling receptor binding extracellular matrix structural constituent Cellular component extracellular matrix laminin-5 complex extracellular region basement membrane laminin-10 complex laminin-11 complex extracellular exosome nucleus extracellular space synaptic cleft neuromuscular junction collagen-containing extracellular matrix Biological process hair follicle development cell differentiation regulation of embryonic development regulation of cell migration cell recognition embryo development lung development muscle organ development extracellular matrix organization morphogenesis of a polarized epithelium odontogenesis of dentin-containing tooth focal adhesion assembly branching involved in ureteric bud morphogenesis regulation of cell adhesion cell adhesion regulation of cell population proliferation cytoskeleton organization angiogenesis neural crest cell migration animal organ morphogenesis integrin-mediated signaling pathway endothelial cell differentiation substrate adhesion-dependent cell spreading morphogenesis of embryonic epithelium cell population proliferation cell migration branching morphogenesis of an epithelial tube branching involved in salivary gland morphogenesis cilium assembly protein localization to plasma membrane cytokine-mediated signaling pathway tissue development cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3911 16776 Ensembl ENSG00000130702 ENSMUSG00000015647 UniProt O15230 Q61001 RefSeq (mRNA) NM_005560 NM_001081171 RefSeq (protein) NP_005551 NP_001074640 Location (UCSC) Chr 20: 62.31 – 62.37 Mb Chr 2: 179.82 – 179.87 Mb PubMed search [3] [4]
Wikidata
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Function

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.^[6]

Interactions

Laminin, alpha 5 has been shown to interact with BCAM.^[7][8]