Laminin, alpha 5

Laminin subunit alpha-5 is a protein that in humans is encoded by the LAMA5 gene.^[5][6]

LAMA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y38
Identifiers
Aliases	LAMA5, Laminin, alpha 5, laminin subunit alpha 5
External IDs	OMIM: 601033; MGI: 105382; HomoloGene: 4060; GeneCards: LAMA5; OMA:LAMA5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 62,307,955 bp[1] End 62,367,312 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 102.7 cM Start 179,818,166 bp[2] End 179,867,652 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum right lung right coronary artery popliteal artery tibial arteries muscle layer of sigmoid colon gastric mucosa upper lobe of left lung skin of abdomen Top expressed in gastrula decidua ascending aorta medullary collecting duct left lung lobe epiblast blastocyst molar aortic valve islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity integrin binding signaling receptor binding extracellular matrix structural constituent Cellular component extracellular matrix laminin-5 complex extracellular region basement membrane laminin-10 complex laminin-11 complex extracellular exosome nucleus extracellular space synaptic cleft neuromuscular junction collagen-containing extracellular matrix Biological process hair follicle development cell differentiation regulation of embryonic development regulation of cell migration cell recognition embryo development lung development muscle organ development extracellular matrix organization morphogenesis of a polarized epithelium odontogenesis of dentin-containing tooth focal adhesion assembly branching involved in ureteric bud morphogenesis regulation of cell adhesion cell adhesion regulation of cell population proliferation cytoskeleton organization angiogenesis neural crest cell migration animal organ morphogenesis integrin-mediated signaling pathway endothelial cell differentiation substrate adhesion-dependent cell spreading morphogenesis of embryonic epithelium cell population proliferation cell migration branching morphogenesis of an epithelial tube branching involved in salivary gland morphogenesis cilium assembly protein localization to plasma membrane cytokine-mediated signaling pathway tissue development cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3911 16776 Ensembl ENSG00000130702 ENSMUSG00000015647 UniProt O15230 Q61001 RefSeq (mRNA) NM_005560 NM_001081171 RefSeq (protein) NP_005551 NP_001074640 Location (UCSC) Chr 20: 62.31 – 62.37 Mb Chr 2: 179.82 – 179.87 Mb PubMed search [3] [4]
Wikidata
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Function

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.^[6]

Interactions

Laminin, alpha 5 has been shown to interact with BCAM.^[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000130702 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015647 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM (Jul 1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". FEBS Letters. 411 (2–3): 296–300. doi:10.1016/S0014-5793(97)00686-8. PMID 9271224. S2CID 45286880.
6. "Entrez Gene: LAMA5 laminin, alpha 5".
7. Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (Jan 2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776. S2CID 10715366.
8. Kikkawa Y, Moulson CL, Virtanen I, Miner JH (Nov 2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". The Journal of Biological Chemistry. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.

Further reading

• Utani A, Nomizu M, Yamada Y (Jan 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences". The Journal of Biological Chemistry. 272 (5): 2814–20. doi:10.1074/jbc.272.5.2814. PMID 9006922.
• Rousselle P, Keene DR, Ruggiero F, Champliaud MF, Rest M, Burgeson RE (Aug 1997). "Laminin 5 binds the NC-1 domain of type VII collagen". The Journal of Cell Biology. 138 (3): 719–28. doi:10.1083/jcb.138.3.719. PMC 2141627. PMID 9245798.
• Tiger CF, Champliaud MF, Pedrosa-Domellof F, Thornell LE, Ekblom P, Gullberg D (Nov 1997). "Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies". The Journal of Biological Chemistry. 272 (45): 28590–5. doi:10.1074/jbc.272.45.28590. PMID 9353324.
• Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Archivum Immunologiae et Therapiae Experimentalis. 45 (2–3): 255–9. PMID 9597096.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Shimizu H, Hosokawa H, Ninomiya H, Miner JH, Masaki T (Apr 1999). "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan". The Journal of Biological Chemistry. 274 (17): 11995–2000. doi:10.1074/jbc.274.17.11995. hdl:2433/180895. PMID 10207021.
• Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS (Jan 2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry. 275 (1): 451–60. doi:10.1074/jbc.275.1.451. PMID 10617638.
• Köhler D, Kruse M, Stöcker W, Sterchi EE (Jan 2000). "Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro". FEBS Letters. 465 (1): 2–7. doi:10.1016/S0014-5793(99)01712-3. PMID 10620696. S2CID 22895580.
• Kikkawa Y, Sanzen N, Fujiwara H, Sonnenberg A, Sekiguchi K (Mar 2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal of Cell Science. 113 ( Pt 5) (5): 869–76. doi:10.1242/jcs.113.5.869. PMID 10671376.
• Champliaud MF, Virtanen I, Tiger CF, Korhonen M, Burgeson R, Gullberg D (Sep 2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta". Experimental Cell Research. 259 (2): 326–35. doi:10.1006/excr.2000.4980. PMID 10964500.
• Libby RT, Champliaud MF, Claudepierre T, Xu Y, Gibbons EP, Koch M, Burgeson RE, Hunter DD, Brunken WJ (Sep 2000). "Laminin expression in adult and developing retinae: evidence of two novel CNS laminins". The Journal of Neuroscience. 20 (17): 6517–28. doi:10.1523/JNEUROSCI.20-17-06517.2000. PMC 2924637. PMID 10964957.
• Pierce RA, Griffin GL, Miner JH, Senior RM (Dec 2000). "Expression patterns of laminin alpha1 and alpha5 in human lung during development". American Journal of Respiratory Cell and Molecular Biology. 23 (6): 742–7. doi:10.1165/ajrcmb.23.6.4202. PMID 11104726.
• Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (Jan 2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776. S2CID 10715366.
• Saghizadeh M, Brown DJ, Castellon R, Chwa M, Huang GH, Ljubimova JY, Rosenberg S, Spirin KS, Stolitenko RB, Adachi W, Kinoshita S, Murphy G, Windsor LJ, Kenney MC, Ljubimov AV (Feb 2001). "Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations". The American Journal of Pathology. 158 (2): 723–34. doi:10.1016/S0002-9440(10)64015-1. PMC 1850323. PMID 11159210.
• McArthur CP, Wang Y, Heruth D, Gustafson S (Jun 2001). "Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53". Archives of Oral Biology. 46 (6): 545–55. doi:10.1016/S0003-9969(01)00014-0. PMID 11311202.
• Gagnoux-Palacios L, Allegra M, Spirito F, Pommeret O, Romero C, Ortonne JP, Meneguzzi G (May 2001). "The short arm of the laminin gamma2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion". The Journal of Cell Biology. 153 (4): 835–50. doi:10.1083/jcb.153.4.835. PMC 2192378. PMID 11352943.
• Nagase T, Kikuno R, Ohara O (Aug 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Doi M, Thyboll J, Kortesmaa J, Jansson K, Iivanainen A, Parvardeh M, Timpl R, Hedin U, Swedenborg J, Tryggvason K (Apr 2002). "Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells". The Journal of Biological Chemistry. 277 (15): 12741–8. doi:10.1074/jbc.M111228200. PMID 11821406.