Importin subunit alpha-4

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.^[5][6]

KPNA3
Identifiers
Aliases	KPNA3, IPOA4, SRP1, SRP1gamma, SRP4, hSRP1, karyopherin subunit alpha 3
External IDs	OMIM: 601892; MGI: 1100863; HomoloGene: 20520; GeneCards: KPNA3; OMA:KPNA3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 49,699,320 bp[1] End 49,792,682 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 61,602,660 bp[2] End 61,677,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii deltoid muscle tibialis anterior muscle vastus lateralis muscle glutes secondary oocyte triceps brachii muscle thoracic diaphragm Top expressed in extensor digitorum longus muscle plantaris muscle zygote secondary oocyte pineal gland triceps brachii muscle tail of embryo vastus lateralis muscle temporal muscle triceps surae More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore nucleus nucleoplasm host cell Biological process protein transport viral entry into host cell viral process viral penetration into host nucleus protein import into nucleus NLS-bearing protein import into nucleus modulation by virus of host cellular process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3839 16648 Ensembl ENSG00000102753 ENSMUSG00000021929 UniProt O00505 O35344 RefSeq (mRNA) NM_002267 NM_008466 RefSeq (protein) NP_002258 NP_032492 Location (UCSC) Chr 13: 49.7 – 49.79 Mb Chr 14: 61.6 – 61.68 Mb PubMed search [3] [4]
Wikidata
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The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60–100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.^[7]

Interactions

KPNA3 has been shown to interact with KPNB1.^[6][8]