John, Johnny, or Jon Hamilton may refer to:
- John Hamilton (painter), British painter
- John R. Hamilton (architect) (fl. 1840–1870), English architect
- John McLure Hamilton (1853–1936), Anglo-American artist
- John Hamilton (actor) (1887–1958), American actor
- John F. Hamilton (1893–1967), American actor
- John "Bugs" Hamilton (1911–1947), American trumpeter
- John Hamilton (artist) (1919–1993), British army officer and artist
- John R. Hamilton (photographer) (1923–1997), American photographer
- John T. Hamilton (born 1963), American literary scholar and musician
- Sterling Hayden (1916–1986), American actor who operated under the code name "John Hamilton" as an agent for the Office of Strategic Services in World War II
- John Hamilton (Jacobite) (died 1691), Irish military officer in the Williamite War in Ireland
- John Hamilton (Royal Navy officer) (1714–1755), British naval officer
- John Hamilton (British Army officer) (1724–1802), British Army officer who served in North America
- John Hamilton (American Revolution) (died 1816), Loyalist military officer in the American Revolutionary War
- Sir John Hamilton, 1st Baronet, of Woodbrook (1755–1835), British and Portuguese general of the Napoleonic Wars
- John Fane Charles Hamilton (1829–1864), British naval officer, after whom the town of Hamilton in New Zealand is named
- John Patrick Hamilton (1896–1961), Australian recipient of the Victoria Cross
- John Brown Hamilton (1896–1973), Scottish recipient of the Victoria Cross
- John Graham Hamilton (1910–1994), British admiral
- John Hamilton (RNZAF officer) (fl. 1971–2006), former Chief of the Royal New Zealand Air Force
- John Hamilton of Cadzow, 4th Laird of Cadzow (before 1370 – c. 1402) Scottish nobleman and soldier
- John Hamilton, 1st Marquess of Hamilton (c. 1535–1604), Scottish nobleman
- John Hamilton, 1st Lord Bargany (died 1658), Scottish peer
- John Hamilton, 4th Earl of Haddington (1626–1669), Scottish nobleman
- John Hamilton, 1st Lord Belhaven and Stenton (died 1679), Scottish peer
- John Hamilton, 2nd Lord Bargany (c. 1640–1693), Scottish peer and soldier
- John Hamilton, 2nd Lord Belhaven and Stenton (1656–1708), Scottish politician and critic of the 1707 Acts of Union
- John Hamilton, 1st Marquess of Abercorn (1756–1818), Scottish nobleman
- John Hamilton, 1st Baron Hamilton of Dalzell (1829–1900), Scottish soldier and politician
- John Hamilton, 1st Viscount Sumner (1859–1934), British law lord
- John d'Henin Hamilton, 3rd Baron Hamilton of Dalzell (1911–1990), Lord Lieutenant of Surrey
- John Hamilton (footballer, born 1880) (1880–?), Scottish footballer for West Ham United
- Johnny Hamilton (footballer, born 1935) (1935–2013), Scottish footballer for Heart of Midlothian
- Johnny Hamilton (footballer, born 1949) (1949–2015), Scottish footballer for Hibernian and Rangers
- Jock Hamilton (A. John Hamilton, 1869–1931), Scottish footballer for Ayr, Wolverhampton Wanderers, Loughborough, Bristol City, Leicester Fosse, Watford, Wellingborough & Fulham
- Jock Hamilton (footballer, born 1879) (John H. Hamilton, 1879–1925), Scottish footballer for Leith Athletic, Leeds City and Brentford, among others
- John Hamilton (architect) (1761–1812), architect and builder in Edinburgh's First New Town, uncle of Thomas Hamilton
- John Church Hamilton (1792–1882), son of the American founding father Alexander Hamilton
- John B. Hamilton (1847–1898), U.S. Surgeon General
- John Hamilton (university chancellor) (1851–1939), Quebec merchant and chancellor of Bishop's University, Lennoxville, Quebec
- John Hamilton (farmer) (fl. 1888–1930), Scottish sheep farming pioneer in Patagonia and landowner in the Falkland Islands
- John Hamilton (gangster) (1899–1934), Canadian murderer and bank-robber and associate of John Dillinger
- John Randle Hamilton (born 1944), American diplomat
- John Maxwell Hamilton (born 1947), journalist, civil servant and educator
- John Hamilton (judge), judge of the Supreme Court of New South Wales, Australia, 1997–2009
- Jon Hamilton, scientist and NPR correspondent