Jethro is a male given name meaning "Friend of God". It is derived from the Hebrew word Yithrô.
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- Kenneth C. "Jethro" Burns (1920–1989), mandolin player in satirical country music duo Homer and Jethro
- Jethro Franklin (born 1965), American football coach
- Jethro J. McCullough (1810–1878), American politician and businessman
- Jethro Pugh (1944–2015), American football player
- Jethro Justinian Harris Teall (1849–1924), British geologist
- Jethro Tull (agriculturist) (1674–1741), British agricultural pioneer
- Jethro Sumner (1733–1785), officer in the American Continental Army
- Jetro Willems (born 1994), Dutch footballer
- Jethro (comedian) (1948–2021), British stand-up comedian, born Geoffrey Rowe
Fictional characters
- Jethro, a character in OK K.O.! Let's Be Heroes
- Jethro, a character in the game GTA: San Andreas
- Jethro (Jerom in the original version), a character in the Belgian comic book series Spike and Suzy
- Jethro Bodine, a character in the American sitcom The Beverly Hillbillies
- Albert Jethro 'A.J.' Chegwidden, a character in JAG
- Jethro Creighton, a character in the novel Across Five Aprils
- Jethro Cane, a character in the Doctor Who episode "Midnight"
- Leroy Jethro Gibbs, a character in NCIS
- Jethro Q. Walrustitty, a character in the Monty Python's Flying Circus sketch "Election Night Special"
- Jethro West, a character in Outrageous Fortune
- Jethro, a character in Micro Machines V3
- Jethro "Jet" Bradley, a character in the video game Tron 2.0
- Jethro Jefferson, a character in the Discworld novel Snuff
- Jethro Tull (band), a mainly 20th-century multiple gold-and-platinum record-releasing British rock group named after the agriculturalist