Jacob is a surname, ultimately from the Biblical figure Jacob. Jakob is the main German form of the name.
For the meaning of the name, see Jacob (name).
A–G
- Abe Jacob (born 1944), American sound designer
- Alaric Jacob (1909–1995), British journalist and author
- Alek Jacob (born 1998), American baseball player
- Alexander Malcolm Jacob (1849–1921), diamond and gemstone trader, sold the Jacob Diamond
- Anund Jacob (c. 1010–1050), a.k.a. Anund Jakob, King of Sweden
- Archibald Jacob (1829–1900), Australian politician
- Archibald Jacob, (1888-1959), British musician, brother of Gordon Jacob
- Ariana Jacob, American artist
- Caroline Jacob (1861–1940), South Australian school principal and owner
- Catherine Jacob (actress) (born 1956), French actress
- Catherine Jacob (journalist) (born 1976), British broadcast journalist and news presenter
- Charles Jacob (geologist) (1878–1962), French geologist
- Charles Jacob (stockbroker) (1921–2015), British stockbroker, promoter of ethical investment
- Charles Donald Jacob (1838–1898), American politician and diplomat
- Christian Jacob (politician) (born 1959), French politician
- Christy Jacob (born 1944), Irish hurler
- Claud Jacob (1863–1948), British soldier
- Claus Jacob (born 1969), German scientist
- Corentin Jacob (born 1997), French footballer
- Daryl Jacob (born 1983), Irish jockey
- E. F. Jacob (1894–1971), British scholar
- Edgar Jacob (1844–1920), British religious leader
- Edward Jacob (c. 1710–1788), British scholar and politician
- Ephraim Arnold Jacob (1845–1905), American lawyer and judge
- François Jacob (1920–2013), French biologist
- Franz G. Jacob (1870–?), German chess master
- Georges Jacob (1739–1814), French artist
- Giles Jacob (1686–1744), British jurist and writer
- Gilles Jacob
- Gordon Jacob (1895–1984), British musician
H–Z
- Heinrich Eduard Jacob (1889–1967), German-American writer
- Ian Jacob (1899–1993), British soldier
- Ida Luise Jacob (1826–1904), German cookbook author; see Emmy Braun (pseudonym)
- Irène Jacob (born 1966) French-born Swiss actress
- Jack Farj Rafael Jacob (1921–2016) Lieutenant general, Indian Army
- John Jacob, Marquess of Montferrat (1395–1445), Italian soldier and government administrator
- John Jacob (East India Company officer) (1812–1858)
- John Edward Jacob (born 1934), American activist
- John J. Jacob (Kentucky businessman) (1770–1852), businessman, industrialist and philanthropist
- John J. Jacob (West Virginia politician) (1829–1893), governor
- Ken Jacob, (born 1949) American politician
- Louis Léon Jacob (1768–1854), French admiral
- Marius Jacob (1879–1954), French activist
- Maurice Jacob (1933-2007), French theoretical particle physicist
- Max Jacob (1876–1944), French writer
- Maxime Jacob, or Dom Clément Jacob, (1906–1977), French monk, composer and organist
- Michael Jacob (born 1980), Irish hurler
- Mick Jacob (born 1946), Irish hurler
- Nancy Jacob, American photographer
- Odile Jacob, French publisher
- Pierre Jacob (1953–2018), Canadian politician
- P. L. Jacob, pseudonym of French writer Paul Lacroix (1806–1884)
- Richard Jacob (born 1958), basketball coach
- Romain Jacob (born 1988), French boxer
- Rory Jacob (born 1983), Irish hurler
- Suzanne Jacob (born 1943), Canadian author
- Teuku Jacob (1929–2007), Indonesian paleoanthropologist
- Teun Jacob (1927–2009), Dutch wall painter and sculptor
- Trevor Jacob (born 1993), American snowboarder accused of deliberately crashing his own plane
- Ursula Jacob (born 1985), Irish camogie player
- Violet Jacob (1863–1946), Scottish writer
- William & Robert (W & R) Jacob, Irish founders of Jacob's biscuit makers
- Little Jacob, supportive character in the plot of GTA IV