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Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.
 | This article is missing information about the history of simeticone. (September 2021) |
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| Clinical data | |
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| Trade names | Infacol, Wind-eze, WindSetlers, many others |
| Other names | simethicone[1] (USAN US) |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Bioavailability | None |
| Protein binding | 0% |
| Metabolism | Not metabolized |
| Elimination half-life | N/A |
| Excretion | Feces |
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| CAS Number | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.107.016 |
| Chemical and physical data | |
| Formula | (C2H6OSi)n · (SiO2)m |
| Molar mass | Variable |
  (what is this?) (verify) | |
Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence.[2][3] While there is a lack of conclusive evidence that simeticone is effective for this use,[4][5][failed verification] studies have shown that it can relieve symptoms of functional dyspepsia[6] and functional bloating.[7]
It has not been fully established that simeticone is useful to treat colic in babies,[8] and it is not recommended for this purpose.[5] A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.[9]
Simeticone can also be used for suspected postoperative abdominal discomfort in infants.[10]
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Simeticone does not have any serious side effects.[11] Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.[12]
Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract.[11] This allows gas bubbles to leave the GI tract as flatulence or belching.[11] Simeticone does not reduce or prevent the formation of gas.[13] Its effectiveness has been shown in several in vitro studies.[14][15]
Simeticone is a mixture of dimethicone and silicon dioxide.[16]
The INN name is "simeticone", which was added to the INN recommended list in 1999.[17]
Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.[18]
Brands |
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Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Polysilane Junior, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.[18] It is also marketed as a combination drug:[18]
It is also marketed as a veterinary drug under the brands Birp and Methysilox. |
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