CD79B

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[5]

CD79B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KG5
Identifiers
Aliases	CD79B, AGM6, B29, IGB, CD79b molecule, Igbeta
External IDs	OMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,928,740 bp[1] End 63,932,336 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 68.89 cM Start 106,202,167 bp[2] End 106,205,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen lymph node appendix apex of heart blood monocyte gonad bone marrow anterior pituitary Top expressed in mesenteric lymph nodes spleen tibiofemoral joint blood bone marrow granulocyte submandibular gland thymus subcutaneous adipose tissue tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity protein homodimerization activity identical protein binding Cellular component integral component of membrane plasma membrane Golgi apparatus integral component of plasma membrane extracellular exosome membrane nucleoplasm external side of plasma membrane B cell receptor complex cytoplasm cytosol Biological process cell surface receptor signaling pathway adaptive immune response immune response signal transduction immune system process B cell differentiation B cell receptor signaling pathway protein homooligomerization response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 974 15985 Ensembl ENSG00000007312 ENSMUSG00000040592 UniProt P40259 P15530 RefSeq (mRNA) NM_000626 NM_001039933 NM_021602 NM_001329050 NM_008339 NM_001313939 RefSeq (protein) NP_000617 NP_001035022 NP_001315979 NP_067613 NP_001300868 NP_032365 Location (UCSC) Chr 17: 63.93 – 63.93 Mb Chr 11: 106.2 – 106.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

Further reading

• Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.
• Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761. S2CID 23910309.
• Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031. S2CID 25093082.
• Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.
• Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. doi:10.1016/S0021-9258(17)32545-0. PMID 7516335.
• Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.
• Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMC 2192043. PMID 7539038.
• Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.
• Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.
• Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.
• Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081. S2CID 6966566.
• Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. doi:10.4049/jimmunol.153.6.2369. PMID 8077654. S2CID 22158525.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. doi:10.4049/jimmunol.150.2.491. PMID 8419481. S2CID 36149482.
• Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.
• Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression". Blood. 87 (2): 666–73. doi:10.1182/blood.V87.2.666.bloodjournal872666. PMID 8555489.
• Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID 8656670.
• Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.
• Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. doi:10.4049/jimmunol.158.7.3062. PMID 9120258. S2CID 20717278.

External links

• CD79B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CD79B genome location and CD79B gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.