CD79B

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[5]

CD79B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KG5
Identifiers
Aliases	CD79B, AGM6, B29, IGB, CD79b molecule, Igbeta
External IDs	OMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,928,740 bp[1] End 63,932,336 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 68.89 cM Start 106,202,167 bp[2] End 106,205,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen lymph node appendix apex of heart blood monocyte gonad bone marrow anterior pituitary Top expressed in mesenteric lymph nodes spleen tibiofemoral joint blood bone marrow granulocyte submandibular gland thymus subcutaneous adipose tissue tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity protein homodimerization activity identical protein binding Cellular component integral component of membrane plasma membrane Golgi apparatus integral component of plasma membrane extracellular exosome membrane nucleoplasm external side of plasma membrane B cell receptor complex cytoplasm cytosol Biological process cell surface receptor signaling pathway adaptive immune response immune response signal transduction immune system process B cell differentiation B cell receptor signaling pathway protein homooligomerization response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 974 15985 Ensembl ENSG00000007312 ENSMUSG00000040592 UniProt P40259 P15530 RefSeq (mRNA) NM_000626 NM_001039933 NM_021602 NM_001329050 NM_008339 NM_001313939 RefSeq (protein) NP_000617 NP_001035022 NP_001315979 NP_067613 NP_001300868 NP_032365 Location (UCSC) Chr 17: 63.93 – 63.93 Mb Chr 11: 106.2 – 106.21 Mb PubMed search [3] [4]
Wikidata
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It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

See also

• Cluster of differentiation