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Tabernanthe iboga (iboga) is an evergreen rainforest shrub native to Central Africa. A member of the Apocynaceae family indigenous to Gabon, the Democratic Republic of Congo, and the Republic of Congo, it is cultivated across Central Africa for its medicinal and other effects.
| Iboga | |
|---|---|
 | |
Scientific classification  | |
| Kingdom: | Plantae |
| Clade: | Tracheophytes |
| Clade: | Angiosperms |
| Clade: | Eudicots |
| Clade: | Asterids |
| Order: | Gentianales |
| Family: | Apocynaceae |
| Genus: | Tabernanthe |
| Species: | T. iboga |
| Binomial name | |
| Tabernanthe iboga | |
In African traditional medicine and rituals, the yellowish root or bark is used to produce hallucinations and near-death outcomes, with some fatalities occurring.[3][4] In high doses, ibogaine is considered to be toxic, and has caused serious comorbidities when used with opioids or prescription drugs.[3][5] The United States Drug Enforcement Administration (DEA) lists ibogaine as a controlled substance of the Controlled Substances Act.[3]
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 | This section needs additional citations for verification. (October 2019) |
T. iboga is native to tropical forests, preferring moist soil in partial shade.[3] It bears dark green, narrow leaves and clusters of tubular flowers on an erect and branching stem, with yellow-orange fruits resembling chili pepper.[3]
Normally growing to a height of 2 m, T. iboga may eventually grow into a small tree up to 10 m tall, given the right conditions. The flowers are yellowish-white or pink and followed by a fruit, orange at maturity, that may be either globose or fusiform. Its yellow-fleshed roots contain a number of indole alkaloids, most notably ibogaine, which is found in the highest concentration in the bark of the roots. The root material, bitter in taste, causes a degree of anaesthesia in the mouth as well as systemic numbness of the skin.[6]
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Publication of binomial
Tabernanthe iboga was described by Henri Ernest Baillon and published in Bulletin Mensuel de la Société Linnéenne de Paris 1: 783 in the year 1889.
Etymology
The genus name Tabernanthe is a compound of the Latin taberna, "tavern"/"hut"/"(market) stall" and Greek: ἄνθος (anthos) "flower" – giving a literal meaning of "tavern flower". On the other hand, it may equally well have been intended (by way of a type of botanical shorthand) to mean "having a flower resembling that of plants belonging to the genus Tabernaemontana " (q.v.). If the first conjecture is the correct one, the name could also have been intended to suggest that the plant is cultivated near huts, sold at market stalls or even that – like the beverages sold at a tavern – the plant is intoxicating, all of which alternatives would constitute apt descriptions of an oft-cultivated and popular psychoactive plant. The specific name iboga comes from the Myene name for the plant,[7] which was also borrowed into a number of other regional languages with mild variation.[8]
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The first (probable...and confused) reference to Iboga is that of Bowdich in chapter 13 of his "Mission from Cape Coast Castle to Ashantee..." of 1819
The Eroga, a favourite but violent medicine, is no doubt a fungus, for they describe it as growing on a tree called the Ocamboo, when decaying; they burn it first, and take as much as would lay on a shilling.
If this is indeed a reference to the drug derived from Tabernanthe iboga (Eroga appears to be a variant form of the names iboga and eboka) it is, of course, grossly in error in its assumption that iboga is not a plant but a fungus. Notable however is the observation of the potency of the drug – effective in small quantities. The description of the plant as growing on a tree is puzzling: Tabernanthe iboga does not usually grow as an epiphyte – if at all.[9][10]
The ritual use of iboga in Africa was first reported by French and Belgian explorers in the 19th century, beginning with the work of French naval surgeon and explorer of Gabon Griffon du Bellay,[11] who identified it correctly as a shrub belonging to the Apocynaceae – as recorded in a short essay by Charles Eugène Aubry-Lecomte on the plant poisons of West Africa, published in the year 1864.
Parmi les plantes rares ou nouvelles rapportées par le docteur Griffon du Bellay, la famille des apocynées contient encore deux poisons; l'un, nommé iboga, n'est toxique qu'à hautes doses et a l'état frais. Pris en petit quantité, il est aphrodisiaque et stimulante du systeme nerveux; les guerriers et chasseurs en font grand usage pour se tenir éveillés dans les affûts de nuit; de même que pour le M'boundou, le principe actif réside dans la racine qu'on mâche comme la coca.
[ Translation: Among the rare or new plants brought back by Dr. Griffon du Bellay, the plant family Apocynaceae contains two further poisons; the first of these, called Iboga, is only toxic in high doses and in the fresh state. Taken in small quantities, it is an aphrodisiac and stimulant of the (central) nervous system; warriors and hunters make considerable use of it in order to stay awake during their night vigils; as with the (plant) M'boundou, the active principle (of Iboga) resides in the root which is chewed like coca (leaf) ].[12]
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Indole alkaloids make up about 6% of the root chemical composition of iboga.[3] Alkaloids that are present in more than 1% in root bark are:[13] (in descending order)
- Ibogaine
- Iboxygaine
- Ibogaline
- Alloibogaine
- Catharanthine
- Ibogamine
- Noribogaine
- Voacangine
- Yohimbine
- Hydroxyibogamine
18-Methoxycoronaridine, a synthetic derivative of ibogaine, also occurs naturally in this plant.[3][4]
The Iboga tree is central to the Bwiti spiritual practices in West-Central Africa, mainly Gabon, Cameroon, and the Republic of the Congo, where the alkaloid-containing roots or bark are used in various ceremonies, sometimes to create a near-death experience.[3][14] Iboga is taken in massive doses by initiates of this spiritual practice, and on a more regular basis is eaten in smaller doses in connection with rituals and tribal dances performed at night.
While in lower doses iboga has a stimulant effect and is used to maintain alertness while hunting,[15][16] in moderate or high doses, iboga induces dream-like states with vivid visions and hallucinations.[3]
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Anecdotal reports of self-treated opioid addicts indicated a reduced desire to sustain opiate abuse following iboga ingestion.[3] Since 1970, iboga has been legally prohibited in the United States following several fatalities.[3][4] Iboga extracts, as well as the purified alkaloid ibogaine, have attracted attention because of their purported ability to reverse addiction to drugs such as alcohol and opiates.[3] Due to the cardiac safety risks of iboga, research is also considering iboga analogues.[17]
Ibogaine is classified as a schedule 1 controlled substance in the United States, and is not approved there for addiction treatment (or any other therapeutic use) because of its hallucinogenic and cardiovascular side effects, as well as the absence of safety and efficacy data in human subjects.[3][5] In most other countries, it remains unregulated and unlicensed.[18]
Independent ibogaine treatment clinics have emerged in Mexico, Canada, the Netherlands, South Africa, and New Zealand, all operating in what has been described as a "legal gray area".[18][19] Covert, illegal neighborhood clinics are also known to exist in the United States, despite active DEA surveillance.[16] Addiction specialists warn that the treatment of drug dependence with ibogaine in non-medical settings, without expert supervision and unaccompanied by appropriate psychosocial care, can be dangerous – and, in approximately one case in 300, potentially fatal.[3][19]
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Ibogaine may induce nausea, vomiting, tremors, and headaches.[3] When ibogaine is used chronically, manic episodes lasting for several days may occur, accompanied by insomnia, irritability, delusions, aggressive behavior, and thoughts of suicide, among other effects.[3][20]
Iboga is outlawed or restricted in Belgium, Poland, Denmark, Croatia, France,[21] Sweden, and Switzerland. In the United States, ibogaine is classified by the Controlled Substances Act on the list of schedule I drugs,[3] although the plant itself remains unscheduled.
Non-profit organization Föreningen för hollistisk missbruksvård is trying to convince the Swedish government to start up clinical investigations of its anti-addictive properties, loosen up the prohibition law against ibogaine, and allow the creation of treatment facilities in Sweden.[22]
Exportation of iboga from Gabon is illegal since the passage of a 1994 cultural protection law.[23]
While little data is available on the exploitation and existing habitat of the iboga plant, the destructive effects of harvesting and slow growth could have already severely damaged the wild iboga population.[24]
- Iboga, les hommes du bois sacré (2002)
- In this French-language film, Gilbert Kelner documents modern Bwiti practices and Babongo perspectives on iboga.[25] Odisea broadcast a Spanish-dubbed version titled Los Hombres de la Madera Sagrada ("The Men of the Sacred Wood").[26]
- Ibogaine: Rite of Passage (2004)
- Directed by Ben Deloenen.[27] A 34-year-old heroin addict undergoes ibogaine treatment with Dr Martin Polanco at the Ibogaine Association, a clinic in Rosarito Mexico. Deloenen interviews people formerly addicted to heroin, cocaine, and methamphetamine, who share their perspectives about ibogaine treatment. In Gabon, a Babongo woman receives iboga root for her depressive malaise. Deloenen visually contrasts this Western, clinical use of ibogaine with the Bwiti use of iboga root bark, but emphasizes the Western context.[28]
- "Babongo" (2005)
- In this episode (series 1, episode 4) of the English documentary series Tribe, presenter Bruce Parry ingests iboga during his time with the Babongo. BBC 2 aired the episode on January 25, 2005.[29]
- "Dosed" (2019)
- This documentary depicts the battle of an opioid addict against her addiction through psychedelic and iboga treatments.
- "Synthetic Ibogaine – Natural Tramadol" (2021)
- In this episode (series 3, episode 4) of the American documentary series Hamilton's Pharmacopeia, presenter Hamilton Morris joins an Iboga ceremony in Gabon and later interviews Chris Jenks who shows a method to produce ibogaine from Voacanga africana.[30]
Plant in fruit: fusiform-fruited form.
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