Intersectin 2

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.^[4][5][6]

ITSN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J3T, 1UDL, 1UE9, 1UFF, 1UHF, 3GF9, 3JZY, 4IIO
Identifiers
Aliases	ITSN2, PRO2015, SH3D1B, SH3P18, SWA, SWAP, intersectin 2
External IDs	OMIM: 604464; MGI: 1338049; HomoloGene: 22627; GeneCards: ITSN2; OMA:ITSN2 - orthologs
Gene location (Mouse) Chr. Chromosome 12 (mouse)[1] Band 12|12 A1.1 Start 4,642,638 bp[1] End 4,763,962 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in zygote granulocyte secondary oocyte iris ciliary body spleen conjunctival fornix neural layer of retina retinal pigment epithelium blood BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component cytoplasm centrosome extracellular exosome Biological process positive regulation of dendrite extension cell differentiation regulation of Rho protein signal transduction endocytosis positive regulation of signal transduction regulation of molecular function viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50618 20403 Ensembl ENSG00000198399 ENSMUSG00000020640 UniProt Q9NZM3 Q9Z0R6 RefSeq (mRNA) NM_147152 NM_006277 NM_019595 NM_001198968 NM_001198969 NM_011365 RefSeq (protein) NP_006268 NP_062541 NP_671494 NP_001335110 NP_001335111 NP_001335112 NP_001335113 NP_001335114 NP_001335115 n/a Location (UCSC) n/a Chr 12: 4.64 – 4.76 Mb PubMed search [2] [3]
Wikidata
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This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.^[6]

Interactions

ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.^[5]