Integrin alpha 8

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[5][6]

ITGA8
Identifiers
Aliases	ITGA8, integrin subunit alpha 8
External IDs	OMIM: 604063; MGI: 109442; HomoloGene: 37396; GeneCards: ITGA8; OMA:ITGA8 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 15,513,954 bp[1] End 15,719,922 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A1|2 9.12 cM Start 12,111,443 bp[2] End 12,306,733 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta urethra right coronary artery saphenous vein gastric mucosa popliteal artery tibial arteries left coronary artery vena cava Top expressed in ascending aorta aortic valve carotid body right lung lobe vas deferens tunica media of zone of aorta left lung lobe vestibular membrane of cochlear duct efferent ductule conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding Cellular component integral component of membrane perikaryon membrane postsynaptic density focal adhesion integrin alpha8-beta1 complex plasma membrane apical part of cell cell surface integrin complex endoplasmic reticulum dendritic spine membrane Biological process positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation kidney development establishment of protein localization extracellular matrix organization memory nervous system development multicellular organism development brain development cell adhesion cell projection organization inner ear morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation smooth muscle tissue development mesodermal cell differentiation integrin-mediated signaling pathway substrate adhesion-dependent cell spreading cell-matrix adhesion metanephros development cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8516 241226 Ensembl ENSG00000077943 ENSMUSG00000026768 UniProt P53708 A2ARA8 RefSeq (mRNA) NM_001291494 NM_003638 NM_001001309 RefSeq (protein) NP_001278423 NP_003629 NP_001001309 NP_001395029 NP_001395030 NP_001395031 Location (UCSC) Chr 10: 15.51 – 15.72 Mb Chr 2: 12.11 – 12.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026768 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. doi:10.1242/jcs.108.2.537. PMID 7768999.
6. "Entrez Gene: ITGA8 integrin, alpha 8".

Further reading

• Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
• Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C". Biochemistry. 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
• Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
• Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111. S2CID 2316181.
• Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
• Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
• Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. Bibcode:2002PNAS...99.8090V. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
• Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1". J. Cell Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
• Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
• Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro". Oncogene. 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

• ITGA8 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine