IRF9

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.^[5][6][7]

IRF9
Identifiers
Aliases	IRF9, IRF-9, ISGF3, ISGF3G, p48, interferon regulatory factor 9
External IDs	OMIM: 147574; MGI: 107587; HomoloGene: 4436; GeneCards: IRF9; OMA:IRF9 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,161,265 bp[1] End 24,166,565 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,841,028 bp[2] End 55,847,487 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte appendix lymph node blood gallbladder right uterine tube anterior pituitary bone marrow bone marrow cells Top expressed in granulocyte Ileal epithelium spleen lymph node seminal vesicula mesenteric lymph nodes thymus blood left lung lobe parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process cell surface receptor signaling pathway regulation of transcription, DNA-templated transcription by RNA polymerase II defense response to virus type I interferon signaling pathway transcription, DNA-templated interferon-gamma-mediated signaling pathway regulation of transcription by RNA polymerase II immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10379 16391 Ensembl ENSG00000213928 ENSG00000285048 ENSMUSG00000002325 UniProt Q00978 Q61179 RefSeq (mRNA) NM_006084 NM_001385400 NM_001385401 NM_001385402 NM_001159417 NM_001159418 NM_008394 RefSeq (protein) NP_006075 NP_001152889 NP_001152890 NP_032420 Location (UCSC) Chr 14: 24.16 – 24.17 Mb Chr 14: 55.84 – 55.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

IRF9 has been shown to interact with STAT2^[8][9] and STAT1.^[8]

References

1. ENSG00000285048 GRCh38: Ensembl release 89: ENSG00000213928, ENSG00000285048 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002325 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol. 12 (8): 3315–24. doi:10.1128/MCB.12.8.3315. PMC 364572. PMID 1630447.
6. McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920. S2CID 40575791.
7. "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa".
8. Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12). UNITED STATES: 6957–64. doi:10.1128/mcb.16.12.6957. ISSN 0270-7306. PMC 231699. PMID 8943351.
9. Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32). UNITED STATES: 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679.

Further reading

• Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology. 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714. S2CID 22135982.
• Reich NC (2002). "Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation". J. Interferon Cytokine Res. 22 (1): 103–9. doi:10.1089/107999002753452719. PMID 11846981.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• David M, Romero G, Zhang ZY, et al. (1993). "In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase". J. Biol. Chem. 268 (9): 6593–9. doi:10.1016/S0021-9258(18)53292-0. PMID 8454630.
• Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
• Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Lau JF, Parisien JP, Horvath CM (2000). "Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7278–83. Bibcode:2000PNAS...97.7278L. doi:10.1073/pnas.97.13.7278. PMC 16536. PMID 10860992.
• Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.
• Chawla-Sarkar M, Leaman DW, Jacobs BS, et al. (2002). "Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)". J. Interferon Cytokine Res. 22 (5): 603–13. doi:10.1089/10799900252982089. PMID 12060499.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. PMC 151539. PMID 12509459.
• Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res. 295 (2): 448–59. doi:10.1016/j.yexcr.2004.01.019. PMID 15093743.
• Sakamoto S, Potla R, Larner AC (2004). "Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes". J. Biol. Chem. 279 (39): 40362–7. doi:10.1074/jbc.M406400200. PMID 15194680.

External links

• ISGF3G+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• IRF9 human gene location in the UCSC Genome Browser.
• IRF9 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.