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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[5]
ILKAP | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1914694; HomoloGene: 31525; GeneCards: ILKAP; OMA:ILKAP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[5]
ILKAP has been shown to interact with Integrin-linked kinase.[6]
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