Interleukin 5 receptor alpha subunit

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.^[5]

IL5RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OBX, 1OBZ, 3QT2, 3VA2
Identifiers
Aliases	IL5RA, CD125, CDw125, HSIL5R3, IL5R, Interleukin 5 receptor alpha subunit, interleukin 5 receptor subunit alpha
External IDs	OMIM: 147851; MGI: 96558; HomoloGene: 473; GeneCards: IL5RA; OMA:IL5RA - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.2 Start 3,066,324 bp[1] End 3,126,613 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E1|6 49.19 cM Start 106,687,318 bp[2] End 106,725,998 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube olfactory zone of nasal mucosa bronchial epithelial cell gonad bone marrow blood bone marrow cells rectum gallbladder monocyte Top expressed in right kidney blood proximal tubule mesenteric lymph nodes morula spleen human kidney thymus uterus CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-5 receptor activity protein binding cytokine receptor activity protein tyrosine kinase activity cytokine binding Cellular component integral component of membrane membrane plasma membrane intracellular anatomical structure extracellular space external side of plasma membrane receptor complex Biological process cellular response to organic substance inflammatory response to antigenic stimulus regulation of interleukin-5 production MAPK cascade cell population proliferation signal transduction interleukin-5-mediated signaling pathway peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway positive regulation of leukocyte proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3568 16192 Ensembl ENSG00000091181 ENSMUSG00000005364 UniProt Q01344 P21183 RefSeq (mRNA) NM_000564 NM_001243099 NM_175724 NM_175725 NM_175726 NM_175727 NM_175728 NM_008370 RefSeq (protein) NP_000555 NP_001230028 NP_783851 NP_783852 NP_783853 NP_783854 NP_783855 NP_032396 Location (UCSC) Chr 3: 3.07 – 3.13 Mb Chr 6: 106.69 – 106.73 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.^[5]

Interactions

Interleukin 5 receptor alpha subunit has been shown to interact with:

• Interleukin 5,^[6][7][8]
• Janus kinase 2,^[9]
• Protein unc-119 homolog,^[10] and
• SDCBP^[11]

See also

• Cluster of differentiation
• Benralizumab
• Mepolizumab
• Reslizumab