Interleukin 1 receptor, type II

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

IL1R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O
Identifiers
Aliases	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDs	OMIM: 147811; MGI: 96546; HomoloGene: 7783; GeneCards: IL1R2; OMA:IL1R2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 101,991,960 bp[1] End 102,028,544 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 18.65 cM Start 40,113,239 bp[2] End 40,164,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis mucosa of sigmoid colon decidua mucosa of pharynx blood right lung epithelium of nasopharynx human penis oral cavity vulva Top expressed in gastrula granulocyte skin of external ear decidua esophagus lip skin of back subcutaneous adipose tissue primary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1, type II, blocking receptor activity protein binding interleukin-1 receptor activity interleukin-1 binding Cellular component integral component of membrane extracellular region plasma membrane membrane cytoplasm Biological process immune response negative regulation of protein processing negative regulation of cytokine production involved in inflammatory response negative regulation of interleukin-1-mediated signaling pathway cytokine-mediated signaling pathway interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7850 16178 Ensembl ENSG00000115590 ENSMUSG00000026073 UniProt P27930 P27931 RefSeq (mRNA) NM_001261419 NM_004633 NM_173343 NM_010555 NM_001360800 NM_001360801 RefSeq (protein) NP_001248348 NP_004624 NP_034685 NP_001347729 NP_001347730 Location (UCSC) Chr 2: 101.99 – 102.03 Mb Chr 1: 40.11 – 40.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,^[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.^[6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.^[7]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type I

References

1. GRCh38: Ensembl release 89: ENSG00000115590 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026073 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, et al. (December 1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
6. Wang D, Zhang S, Li L, Liu X, Mei K, Wang X (October 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.
7. "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

Further reading

• McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, et al. (October 1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821–2832. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
• Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP (October 1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry. 266 (30): 20311–20315. doi:10.1016/S0021-9258(18)54924-3. PMID 1834644.
• Fasano MB, Cousart S, Neal S, McCall CE (November 1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation. 88 (5): 1452–1459. doi:10.1172/JCI115454. PMC 295647. PMID 1834697.
• Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J (September 1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation; A Journal of Technical Methods and Pathology. 73 (3): 347–355. PMID 7564267.
• Symons JA, Young PR, Duff GW (February 1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1714–1718. Bibcode:1995PNAS...92.1714S. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046.
• Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, et al. (November 1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology. 153 (10): 4766–4774. doi:10.4049/jimmunol.153.10.4766. PMID 7963543. S2CID 23226920.
• Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, et al. (December 1994). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802–5809. doi:10.4049/jimmunol.153.12.5802. PMID 7989776. S2CID 20750506.
• Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, Mantovani A, et al. (February 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine. 179 (2): 739–743. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881.
• Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, et al. (July 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–475. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
• Sambo P, Fadlon EJ, Sironi M, Matteucci C, Introna M, Mantovani A, et al. (March 1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood. 87 (5): 1682–1686. doi:10.1182/blood.V87.5.1682.bloodjournal8751682. PMID 8634411.
• Larregina A, Morelli A, Kolkowski E, Fainboim L (February 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology. 87 (2): 317–325. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397.
• Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, De Souza EB (August 1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry. 271 (34): 20965–20972. doi:10.1074/jbc.271.34.20965. PMID 8702856.
• Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M, et al. (April 1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology. 156 (7): 2534–2541. doi:10.4049/jimmunol.156.7.2534. PMID 8786316. S2CID 7669945.
• Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (August 1996). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636–641. doi:10.1006/cyto.1996.0085. PMID 8894439.
• Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, et al. (November 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–122. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
• van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (January 1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases. 175 (1): 118–122. doi:10.1093/infdis/175.1.118. PMID 8985204.
• Rauschmayr T, Groves RW, Kupper TS (May 1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America. 94 (11): 5814–5819. Bibcode:1997PNAS...94.5814R. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157.
• Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, et al. (June 1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513–1526. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
• Cannon JG, Angel JB, Abad LW, Vannier E, Mileno MD, Fagioli L, et al. (May 1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology. 17 (3): 253–261. doi:10.1023/A:1027314713231. PMID 9168406. S2CID 13013291.
• Fink GW, Norman JG (December 1997). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine. 9 (12): 1023–1027. doi:10.1006/cyto.1997.0260. PMID 9417814.

External links

• IL1R2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.