Bacterial initiation factor 2

"IF-2" redirects here. For other uses, see IF2.

Bacterial initiation factor-2 is a bacterial initiation factor.^[1]

Translation initiation factor IF-2, bacterial-like
Identifiers
Symbol	?
InterPro	IPR000178

IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA_f binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and P_i, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.

Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.^[2]

References

1. Prokaryotic+Initiation+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
2. D'Souza AR, Minczuk M (July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry. 62 (3): 309–320. doi:10.1042/EBC20170102. PMC 6056719. PMID 30030363.