Infected cell protein 47

Infected cell protein 47 also ICP-47 or ICP47 is a protein encoded by the viruses such as Herpes simplex virus and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response by interfering with an infected cell's ability to show viral epitopes to T cells.^[1] Its secondary structure shows three helices.

US12
Identifiers
Symbol	Herpes_US12
Pfam	PF05363
InterPro	IPR008026
CATH	5U1D
SCOP2	1qlo / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Method of action

It works by inhibiting transfer of viral particles to the human TAP proteins and thus entry of viral peptides into the endoplasmic reticulum, which is supposed to bind them to MHC class I molecules^[1] for extracellular T-cell recognition so the viral component will trigger immune defense response as a foreign entity.^[2] However human or some animal TAP proteins differs in mice making rodents far less susceptible than humans to HSV.