Hydrocodone/homatropine

Hydrocodone/homatropine, sold under the brand name Tussigon among others, is a fixed-dose combination medication used for the treatment of cough.^[1][2] It contains hydrocodone, as the bitartrate, an opioid agonist; and homatropine, as the methylbromide, a muscarinic antagonist.^[1][2] It is taken by mouth.^[1][2]

Hydrocodone/homatropine

Combination of
Hydrocodone	Opioid agonist
Homatropine	Muscarinic antagonist
Clinical data
Trade names	Tussigon, Hycodan, Hydromet, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Hydrocodone and homatropine
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	US: Schedule II[1][2]
Identifiers
CAS Number	8013-91-0
KEGG	D11076

Hydrocodone/homatropine was approved for medical use in the United States in 1943.^[1][2]

Adverse effects

In the US, the label for hydrocodone/homatropine contains a black box warning about addiction, abuse, and misuse.^[1][2]

References

1. "Hycodan- hydrocodone bitartrate and homatropine methylbromide tablet; Hycodan- hydrocodone bitartrate and homatropine methylbromide solution". DailyMed. 29 December 2021. Retrieved 23 December 2023.
2. "Hydromet- hydrocodone bitartrate and homatropine methylbromide solution". DailyMed. 30 September 2022. Retrieved 23 December 2023.