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Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene.[2][3][4] It is used to treat high blood pressure and edema (swelling).[2][3][4] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide.[2][3] It is taken by mouth.[2][3][4]
| Combination of | |
|---|---|
| Hydrochlorothiazide | Thiazide diuretic |
| Triamterene | Potassium-sparing diuretic |
| Clinical data | |
| Trade names | Dyazide, Maxzide, others |
| Other names | co-triamterzide |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[2][3] Other serious side effects may include high blood potassium.[2][3] Use in pregnancy and breastfeeding is not generally recommended.[2][3] Use in those with significant kidney problems is not recommended.[2][3] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[2][3]
The combination was approved for medical use in the United States in 1965.[5] In 2022, it was the 116th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[6][7]
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