The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.
Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.
List of hydrazine antidepressants
Marketed
- Benmoxin (Neuralex, Nerusil) ‡
- Iproclozide (Sursum) ‡
- Iproniazid (Marsilid) ‡
- Isocarboxazid (Marplan)
- Mebanazine (Actomol) ‡
- Nialamide (Niamid) ‡
- Octamoxin (Ximaol, Nimaol) ‡
- Phenelzine (Nardil)
- Pheniprazine (Catron) ‡
- Phenoxypropazine (Drazine) ‡
- Pivhydrazine (Tersavid) ‡
- Safrazine (Safra) ‡
Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs.
Never marketed
Parkinson's
Tranquillosedative
- Centazolone
References
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