Hes family bhlh transcription factor 2

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.^[5]

HES2
Identifiers
Aliases	HES2, bHLHb40, hes family bHLH transcription factor 2
External IDs	OMIM: 609970; MGI: 1098624; HomoloGene: 22455; GeneCards: HES2; OMA:HES2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,412,418 bp[1] End 6,424,670 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 82.92 cM Start 152,243,324 bp[2] End 152,246,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of esophagus mucosa of transverse colon buccal mucosa cell placenta skin of abdomen gingival epithelium skin of leg vagina right uterine tube olfactory zone of nasal mucosa Top expressed in embryo lip jejunum right kidney proximal tubule duodenum yolk sac Ileal epithelium esophagus lens More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding double-stranded DNA binding transcription factor binding protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleus Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II somitogenesis Notch signaling pathway cell differentiation regulation of neurogenesis anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54626 15206 Ensembl ENSG00000069812 ENSMUSG00000028940 UniProt Q9Y543 O54792 RefSeq (mRNA) NM_019089 NM_001301805 NM_008236 RefSeq (protein) NP_061962 NP_001288734 NP_032262 Location (UCSC) Chr 1: 6.41 – 6.42 Mb Chr 4: 152.24 – 152.25 Mb PubMed search [3] [4]
Wikidata
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References

1. GRCh38: Ensembl release 89: ENSG00000069812 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028940 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Hes family bHLH transcription factor 2".

Further reading

• Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
• Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.