Hydroxycarboxylic acid receptor 3

Hydroxycarboxylic acid receptor 3 (HCA₃), also known as niacin receptor 2 (NIACR2) and GPR109B,^[5] is a protein which in humans is encoded by the HCAR3 gene.^[6][7] HCA₃, like the other hydroxycarboxylic acid receptors HCA₁ and HCA₂, is a G_i/o-coupled G protein-coupled receptor (GPCR).^[5][8] The primary endogenous agonists of HCA₃ are 3-hydroxyoctanoic acid and kynurenic acid.^[5][8][9] HCA₃ is also a low-affinity biomolecular target for niacin (aka nicotinic acid).^[10]

HCAR3
Identifiers
Aliases	HCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs	OMIM: 606039; MGI: 1933383; HomoloGene: 130547; GeneCards: HCAR3; OMA:HCAR3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,714,756 bp[1] End 122,716,811 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 124,001,633 bp[2] End 124,003,562 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte gonad spleen monocyte mucosa of esophagus bone marrow skin of abdomen skin of leg appendix Top expressed in granulocyte esophagus lip skin of external ear morula subcutaneous adipose tissue skin of back transitional epithelium of urinary bladder trachea skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8843 80885 Ensembl ENSG00000255398 ENSMUSG00000045502 UniProt P49019 Q9EP66 RefSeq (mRNA) NM_006018 NM_030701 RefSeq (protein) NP_006009 NP_109626 Location (UCSC) Chr 12: 122.71 – 122.72 Mb Chr 5: 124 – 124 Mb PubMed search [3] [4]
Wikidata
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