HIST1H4G

Histone H4-like protein type G is a protein that in humans is encoded by the HIST1H4G gene.^[3][4][5]

H4C7
Identifiers
Aliases	H4C7, H4/l, H4FL, histone cluster 1, H4g, histone cluster 1 H4 family member g, H4 clustered histone 7, HIST1H4G
External IDs	OMIM: 602832; HomoloGene: 48222; GeneCards: H4C7; OMA:H4C7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,246,611 bp[1] End 26,246,996 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle optic nerve deltoid muscle cell somatic cell mononuclear cell cerebral cortex monocyte rectum small intestine n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity DNA binding histone binding molecular function Cellular component nucleosome nucleus chromosome Biological process nucleosome assembly biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8369 n/a Ensembl ENSG00000275663 n/a UniProt Q99525 n/a RefSeq (mRNA) NM_003547 n/a RefSeq (protein) NP_003538 n/a Location (UCSC) Chr 6: 26.25 – 26.25 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000275663 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
5. "Entrez Gene: HIST1H4G histone cluster 1, H4g".

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.