H2BFWT

H2B histone family, member W, testis-specific is a protein that in humans is encoded by the H2BFWT gene.^[3]

H2BW1
Identifiers
Aliases	H2BW1, H2B histone family member W, testis specific, H2BFWT, H2B.W histone 1, TH2B-175
External IDs	OMIM: 300507; HomoloGene: 128214; GeneCards: H2BW1; OMA:H2BW1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.2 Start 104,011,147 bp[1] End 104,013,708 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis placenta left testis right coronary artery prefrontal cortex tonsil superior frontal gyrus blood n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein heterodimerization activity Cellular component nucleosome nuclear membrane membrane nucleus chromosome Biological process nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 158983 n/a Ensembl ENSG00000123569 n/a UniProt Q7Z2G1 n/a RefSeq (mRNA) NM_001002916 n/a RefSeq (protein) NP_001002916 n/a Location (UCSC) Chr X: 104.01 – 104.01 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Jan 2010].^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000123569 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: H2B histone family, member W, testis-specific". Retrieved 2012-03-12.

Further reading

• Churikov D, Zalenskaya IA, Zalensky AO (2004). "Male germline-specific histones in mouse and man". Cytogenetic and Genome Research. 105 (2–4): 203–14. doi:10.1159/000078190. PMID 15237208. S2CID 35801583.
• Churikov D, Siino J, Svetlova M, Zhang K, Gineitis A, Morton Bradbury E, Zalensky A (October 2004). "Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome". Genomics. 84 (4): 745–56. doi:10.1016/j.ygeno.2004.06.001. PMID 15475252.
• Boulard M, Gautier T, Mbele GO, Gerson V, Hamiche A, Angelov D, Bouvet P, Dimitrov S (February 2006). "The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes". Molecular and Cellular Biology. 26 (4): 1518–26. doi:10.1128/MCB.26.4.1518-1526.2006. PMC 1367197. PMID 16449661.
• Lee J, Park HS, Kim HH, Yun YJ, Lee DR, Lee S (August 2009). "Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility". Journal of Cellular and Molecular Medicine. 13 (8B): 1942–51. doi:10.1111/j.1582-4934.2009.00830.x. PMC 6529973. PMID 19583817.