Growth-hormone-releasing hormone receptor

Receptor protein that binds with somatcrinin From Wikipedia, the free encyclopedia

Growth-hormone-releasing hormone receptor

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.[5] GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone.

Quick Facts GHRHR, Available structures ...
GHRHR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDsOMIM: 139191; MGI: 95710; HomoloGene: 640; GeneCards: GHRHR; OMA:GHRHR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000823
NM_001009824

NM_001003685

RefSeq (protein)

NP_000814

NP_001003685

Location (UCSC)Chr 7: 30.94 – 30.99 MbChr 6: 55.35 – 55.37 Mb
PubMed search[3][4]
Wikidata
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Function

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[6]

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