The House of Orsini is an Italian noble family that was one of the most influential princely families in medieval Italy and Renaissance Rome. Members of
six sons of Ferdinando III Orsini, duke of Gravina, and Giovanna Frangipani della Tolfa, from Toritto. A member of the Orsini of Rome, he was the fifth
(1489–1528) was the daughter of Piero di Lorenzo de' Medici and Alfonsina Orsini. Born in Florence, she was the granddaughter of Lorenzo de' Medici, niece