George Clark may refer to:
- Sir George Clark, 1st Baronet (1861–1935), businessman and politician in Northern Ireland
- Sir George Clark, 2nd Baronet (1883–1950)
- Sir George Clark, 3rd Baronet (1914–1991), unionist politician and Orangeman
- George Clark (New Orleans), mayor of New Orleans, 1866
- George Clark (Queensland politician) (1834–1907), member of the Legislative Assembly of Queensland for Warwick
- George Daniel Clark (1848–1933), Australian politician
- George T. Clark (1837–1888), American politician
- George Washington Clark (1834–1898), mayor of Charleston, South Carolina
- George Rogers Clark (1752–1818), American Revolutionary War military leader
- George Ramsey Clark (1857–1945), United States Navy admiral
- George Clark (cartoonist) (1902–1981), creator of The Neighbors
- George Kitson Clark (1900–1975), English historian
- George H. Clark (1872–1943), Republican lawyer and judge from Ohio
- George M. Clark (1875–1951), American jurist
- George Thomas Clark (1809–1898), British engineer and antiquary
- George Clark (activist) (1926–20??), a founding member of the 'Committee of 100' and housing activist in Notting Hill
- George Clark (producer) (1888–1946), British film producer
- George Aitken Clark (1823–1873), Scottish manufacturer and benefactor
- George Clark (British Army officer) (1892–1948), senior British Army officer
- George Makana Clark, Zimbabwean writer
- George Clark (priest) (1810–1874), archdeacon of St David's