CLC (gene)

CLC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1G86, 1HDK, 1LCL, 1QKQ
Identifiers
Aliases	CLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10
External IDs	OMIM: 153310; HomoloGene: 130498; GeneCards: CLC; OMA:CLC - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,738,029 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; bone marrow cells; ; testicle; ; monocyte; ; blood; ; gallbladder; ; appendix; ; granulocyte; ; mucosa of transverse colon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase activity involved in apoptotic process; lysophospholipase activity; protein binding; carbohydrate binding; identical protein binding;
Cellular component	cytoplasm; cytosol; collagen-containing extracellular matrix;
Biological process	multicellular organism development; T cell apoptotic process; regulation of T cell cytokine production; regulation of activated T cell proliferation; regulation of T cell anergy;
	Sources:Amigo / QuickGO
Orthologs
	1178
	n/a
	ENSG00000105205
	n/a
	Q05315
	n/a
	NM_001828
	n/a
	NP_001819
	n/a
	Wikidata
View/Edit Human

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.^[3]^[4]

Quick Facts Available structures, PDB ...

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Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[4]

See also