Glutathione peroxidase 5

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.^[5][6]

GPX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I3Y
Identifiers
Aliases	GPX5, HEL-S-75p, glutathione peroxidase 5, GPx-5, EGLP, GSHPx-5
External IDs	OMIM: 603435; MGI: 104886; HomoloGene: 1155; GeneCards: GPX5; OMA:GPX5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 28,525,881 bp[1] End 28,534,955 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.1|13 7.73 cM Start 21,470,599 bp[2] End 21,476,901 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis superior frontal gyrus prefrontal cortex islet of Langerhans prostate canal of the cervix blood human musculoskeletal system skeletal muscle Top expressed in morula Ileal epithelium blastocyst perirhinal cortex entorhinal cortex dorsal striatum CA3 field white adipose tissue epidermis adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity peroxidase activity glutathione peroxidase activity Cellular component sperm plasma membrane extracellular region extracellular space Biological process cellular oxidant detoxification response to oxidative stress lipid metabolism cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2880 14780 Ensembl ENSG00000257770 ENSG00000224586 ENSMUSG00000004344 UniProt O75715 P21765 RefSeq (mRNA) NM_001509 NM_003996 NM_010343 RefSeq (protein) NP_001500 NP_003987 NP_034473 Location (UCSC) Chr 6: 28.53 – 28.53 Mb Chr 13: 21.47 – 21.48 Mb PubMed search [3] [4]
Wikidata
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GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[5]