GPRC6A

G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.^[5] This protein functions as a receptor of L-α-amino acids,^[6] cations (e.g., calcium),^[7] osteocalcin,^[8] and steroids.^[9] It is a membrane androgen receptor.

GPRC6A
Identifiers
Aliases	GPRC6A, GPCR, bA86F4.3, G protein-coupled receptor class C group 6 member A
External IDs	OMIM: 613572; MGI: 2429498; HomoloGene: 17529; GeneCards: GPRC6A; OMA:GPRC6A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 116,792,085 bp[1] End 116,829,083 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 51,490,919 bp[2] End 51,507,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad salivary gland minor salivary glands islet of Langerhans human kidney right adrenal gland right adrenal cortex muscle of thigh left adrenal gland Top expressed in embryo embryo left lung lobe right lung lobe islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane intracellular anatomical structure membrane integral component of plasma membrane Biological process response to amino acid calcium-mediated signaling signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 222545 210198 Ensembl ENSG00000173612 ENSMUSG00000019905 UniProt Q5T6X5 Q8K4Z6 RefSeq (mRNA) NM_148963 NM_001286354 NM_001286355 NM_153071 RefSeq (protein) NP_001273283 NP_001273284 NP_683766 NP_694711 Location (UCSC) Chr 6: 116.79 – 116.83 Mb Chr 10: 51.49 – 51.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.^[10]

See also

• ZIP9

References

1. GRCh38: Ensembl release 89: ENSG00000173612 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019905 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
6. Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
7. Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
8. Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
9. Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.
10. Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC 3183291. PMID 21681779.

Further reading

• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene. 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
• Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
• Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

External links

• GPRC6A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• "Calcium-Sensing Receptors: GPRC₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.