Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases.
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Names | |
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IUPAC name
Guanosine 5′-(α-D-mannopyranosyl dihydrogen diphosphate) | |
Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} O3-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen diphosphate | |
Identifiers | |
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ChemSpider | |
MeSH | Guanosine+Diphosphate+Mannose |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C16H25N5O16P2 | |
Molar mass | 605.341 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Known as donor of activated mannose in all glycolytic reactions, GDP-mannose is essential in eukaryotes.[1]
Biosynthesis
GDP-mannose is produced from GTP and mannose-6-phosphate by the enzyme mannose-1-phosphate guanylyltransferase (GDP-mannose pyrophosphorylase, GDP-MP).[2] This enzyme belongs to a family of nucleotidyl-transferases and is a pervasive enzyme found in bacteria, fungi, plants, and animals.[3]