Frederick, Frederic or Fred Smith may refer to:
- Frederick Smith, 1st Baron Colwyn (1859–1946), British businessman
- Frederick Smith, 2nd Viscount Hambleden (1868–1928), British businessman and politician
- Frederic L. Smith (1870–1954), American football player and automobile industry pioneer in Detroit, Michigan
- Frederick Smith, 2nd Baron Colwyn (1914–1966), stockbroker and British Army officer, grandson of the 1st Baron Colwyn
- Frederick W. Smith (born 1944), American businessman, founder of FedEx
- Frederick Smith (Pennsylvania lawyer) (1773–1830), Pennsylvania lawyer, state attorney general, state Supreme Court justice
- Frederick Chatfield Smith (1823–1905), British Member of Parliament for North Nottinghamshire, 1868–1880
- Sir Frederick Smith (South African politician) (1861–1926), South African businessman and mayor of Cape Town
- Fred Smith (New Brunswick politician) (1871–1941), Member of the Legislative Assembly of New Brunswick
- F. E. Smith, 1st Earl of Birkenhead (Frederick Edwin Smith, 1872–1930), British Conservative statesman, attorney-general and lord chancellor
- Frederick Smith (Australian politician) (1883–1960), Australian politician, government minister in Western Australia
- Frederick Cleveland Smith (1884–1956), U. S. representative from Ohio
- Fred A. Smith (trade unionist) (1887–1943), British trade unionist
- Fred J. Smith (died 1988), member of the Illinois legislature, 1943–1979
- Frederick Plympton Smith (1915–1985), member of the Vermont House of Representatives and Vermont Senate
- Sir Frederick Smith (Barbadian barrister) (1924–2016), Attorney General of Barbados and Chief Justice of Turks and Caicos
- Fred Smith (North Carolina politician) (born 1942), American politician; North Carolina legislator and attorney
- Fred Smith (Arkansas politician), former professional basketball player and member of the Arkansas House of Representatives
- Fred L. Smith (political writer), American think-tank leader
- Fred Smith, program director at Maryville Academy and candidate in the United States House of Representatives elections in Illinois, 2010
- Fred Smith (footballer, born 1887) (1887–1957), English footballer with Stockport County, Derby County, Macclesfield and Southampton in the 1900s and 1910s
- Fred Smith (footballer, born 1898) (1898–1971), English footballer with Bury
- Fred Smith (footballer, born 1901) (1901–?), English football centre forward
- Fred Smith (Port Vale footballer) (fl. 1925–1927), English footballer at outside left with Port Vale in the 1920s
- Frederick Smith (footballer) (fl. 1930–1938), English footballer at outside right with Stockport County, Darlington, Exeter City and Gillingham in the 1930s
- Fred Smith (footballer, born 1914) (1914–1982), English footballer with Bury and Bradford
- Fred Smith (footballer, born February 1926) (1926–2005), Scottish footballer with Aberdeen, Hull City, Sheffield United and Millwall
- Fred Smith (footballer, born May 1926) (1926–2017), English footballer with Sheffield United and Grimsby
- Fred Smith (footballer, born 1942) (1942-2020), English footballer with Burnley and Portsmouth
Rugby league
- Fred Smith (rugby league, born c. 1885), English rugby league footballer of the 1900s and 1910s for Great Britain, England, and Hunslet
- Fred Smith (1930s rugby league), rugby league centre who played in the 1930s for Wakefield Trinity
- Fred Smith (rugby league, born 1935) (1935–2004), English rugby league footballer of the 1950s and 1960s for Yorkshire, Leeds, and Wakefield Trinity