Frank is a German surname. Notable persons with the surname include:
- Alan Frank (1910–1994), music publisher, clarinetist, composer
- Amber Frank (born 1998), American actress
- Bob Frank (1944–2019), American musician, singer, songwriter
- Jackson C. Frank (1943–1999), American folk musician
- Jason David Frank (1973–2022), American actor
- Tony Frank (1943–2000), American actor
- Anne Frank (1929–1945), author of a famous diary during World War II
- Edith Frank (1900–1945), mother of Anne Frank
- Margot Frank (1926–1945), sister of Anne Frank
- Otto Frank (1889–1980), father of Anne Frank and posthumous editor of her works
- Bernard Frank (1929–2006), French journalist and writer
- Bruno Frank (1878–1945), German author, poet, dramatist and humanist
- Dan Frank (1954–2021), American editorial director at Pantheon Books
- Leonhard Frank (1882–1961), German writer
- Nathaniel Frank (fl. 2000s), American author and historian
- Waldo Frank (1889–1967), American author and scholar
- Thomas Frank (born 1965), American political analyst, historian, and writer
- Barney Frank (born 1940), American politician, Massachusetts Democratic congressperson
- Donald J. Frank (1937–1995), American politician from Minnesota
- Ivo Frank (1877–1939), Croatian lawyer and politician
- James Frank (born 1966), American politician, Republican member of the Texas House of Representatives from Wichita Falls
- Josip Frank (1844–1911), Croatian lawyer and politician of Jewish descent
- Michael Frank (1804–1894), American politician from Wisconsin
- William J. Frank (born 1960), American politician, Maryland Republican state congressperson since 2003
- Adolph Frank (1834–1916), German chemist
- Albert Bernhard Frank (1839–1900), German biologist
- András Frank (born 1949), Hungarian mathematician
- Dawn Frank, American biologist and academic administrator
- Frederick Charles Frank (1911–1998), British physicist, crystallographer
- Joachim Frank (born 1940), German-American biophysicist and Nobel laureate
- Johann Peter Frank (1745–1821), German physician and hygienist
- Ilya Frank (1908–1990), physicist and 1958 Nobel laureate
- Philipp Frank (1884–1966), physicist, mathematician and philosopher
- Dr. Nicholas Frank, English-American Veterinarian and Dean of Mississippi State University College of Veterinary Medicine
- Andre Gunder Frank (1929–2005), German-American sociologist known as a founder of dependency theory
- Bernard Frank (wilderness activist) (1902–1964), wilderness activist and co-founder of The Wilderness Society
- Donovan W. Frank (born 1951), American judge
- Eugene Maxwell Frank (1907–2009), American Bishop of the Methodist and United Methodist Churches
- Eve Frank (1754–1816/1817), female Jewish messiah claimant
- Harriet Frank Jr. (1923–2020), American screenwriter and film producer
- Helmar Frank (1933–2013), German mathematician and educator
- Henry Frank (1851–1908), Montana entrepreneur
- Jacob Frank (1726–1791), Polish founder of a Jewish dissident sect
- Jerome Frank (1889–1957), American legal philosopher and judge
- Joe Frank (1938–2018), American writer, teacher, and radio performer
- Leo Frank (1884–1915), man convicted of murdering a 13-year-old girl in Georgia
- Lisa Frank (born 1955), American businesswoman
- Peter Frank (academic) (1934–2013), British professor and media commentator
- Peter Frank (art critic) (born 1950), art critic, curator, and poet
- Ray Frank (1861–1948), female Jewish religious leader
- Robert Frank (1924–2019), photographer
- Robert H. Frank (born 1945), economist
- Semyon Frank, (1877–1950) Russian philosopher
- Peirson Frank (1881–1951), British civil engineer
- Ulrich Frank (born 1958), German computer scientist