First Blood is a 1982 film starring Sylvester Stallone also known as "Rambo 1".
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First Blood may also refer to:
- "First Blood" (short story), a 1930 short story by F. Scott Fitzgerald
- First Blood, a 1953 novel by Jack Schaefer
- First Blood (novel), a 1972 novel by David Morrell, basis for the 1982 film
- First Blood, a 1980 novel by Charles Whiting, under the pseudonym Klaus Konrad
- First Blood, a 1983 novel by Elizabeth Smither
- The First Blood, a 1992 novel by Lou Cameron
- First Blood, a 1993 novel by Claire Rayner
- First Blood, a 2003 short story anthology by Lynn Abbey, the fifth Thieves' World omnibus
- First Blood, a 2008 short story anthology by Meljean Brook, Chris Marie Green, Erin McCarthy and Susan Sizemore
- First Blood, a 2019 novel by Angela Marsons
- First Blood, a 2021 novel by Amélie Nothomb
- First Blood, a 2022 novel by Zelda Knight
- First Blood match, a type of professional wrestling match
- Rambo (franchise), also known as the First Blood franchise
- First Blood is a painting depicting 14-year-old Prince William with his face blooded, wearing ermine robes and with a dead stag