Eugene or Gene Klein may refer to:
- Gene Klein (1921–1990), American entrepreneur and sportsman
- Gene Klein (soccer) (1952–2023), American soccer coach
- Eugene Klein (philatelist) (1878–1944), American stamp collector
- Gene Simmons (born 1949), aka Gene Klein, American rock musician
- Eugene Klein, American cellist with the Delaware Symphony Orchestra
See also
- Jean Klein (disambiguation)
- Gene Clines, American baseball player
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