EEF2

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G.^[5][6][7][8]

EEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X
Identifiers
Aliases	EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2
External IDs	OMIM: 130610; MGI: 95288; HomoloGene: 134867; GeneCards: EEF2; OMA:EEF2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,976,056 bp[1] End 3,985,463 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,012,465 bp[2] End 81,018,332 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland cartilage tissue stromal cell of endometrium external globus pallidus corpus epididymis caput epididymis lateral nuclear group of thalamus pars reticulata Achilles tendon epithelium of colon Top expressed in Gonadal ridge molar lacrimal gland transitional epithelium of urinary bladder maxillary prominence mandibular prominence dentate gyrus of hippocampal formation granule cell somite ankle mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ribosome binding GTP binding p53 binding translation elongation factor activity actin filament binding protein binding 5S rRNA binding protein kinase binding RNA binding GTPase activity cadherin binding Cellular component cytoplasm polysome membrane plasma membrane aggresome membrane raft extracellular exosome nucleus polysomal ribosome extracellular matrix extracellular region cytosol secretory granule lumen ficolin-1-rich granule lumen synapse ribonucleoprotein complex Biological process response to estradiol positive regulation of cytoplasmic translation skeletal muscle contraction translational elongation ageing positive regulation of translation response to endoplasmic reticulum stress cellular response to brain-derived neurotrophic factor stimulus response to ischemia hematopoietic progenitor cell differentiation peptidyl-diphthamide biosynthetic process from peptidyl-histidine glial cell proliferation skeletal muscle cell differentiation response to folic acid response to ethanol response to hydrogen peroxide protein biosynthesis protein methylation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1938 13629 Ensembl ENSG00000167658 ENSMUSG00000034994 UniProt P13639 P58252 RefSeq (mRNA) NM_001961 NM_007907 RefSeq (protein) NP_001952 NP_031933 Location (UCSC) Chr 19: 3.98 – 3.99 Mb Chr 10: 81.01 – 81.02 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.^[7]

aEF2/eEF2 found in most archaea and eukaryotes, including humans, contains a post translationally modified histidine diphthamide.^[8] It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa).^[9] The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.