ELAV-like protein 3

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.^[5][6]

ELAVL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D8Z, 1D9A, 1FNX
Identifiers
Aliases	ELAVL3, HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDs	OMIM: 603458; MGI: 109157; HomoloGene: 31035; GeneCards: ELAVL3; OMA:ELAVL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 11,451,326 bp[1] End 11,481,046 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 8.07 cM Start 21,926,301 bp[2] End 21,963,319 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex ventral tegmental area superior vestibular nucleus ganglionic eminence cerebellar cortex paraflocculus of cerebellum cerebellar vermis Pons Top expressed in Rostral migratory stream cerebellar cortex lobe of cerebellum cerebellar vermis habenula superior frontal gyrus ganglionic eminence subiculum pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1995 15571 Ensembl ENSG00000196361 ENSMUSG00000003410 UniProt Q14576 Q60900 RefSeq (mRNA) NM_001420 NM_032281 NM_010487 RefSeq (protein) NP_001411 NP_115657 NP_034617 Location (UCSC) Chr 19: 11.45 – 11.48 Mb Chr 9: 21.93 – 21.96 Mb PubMed search [3] [4]
Wikidata
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A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]