Excitatory amino acid transporter 5

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.^[5][6]

SLC1A7
Identifiers
Aliases	SLC1A7, AAAT, EAAT5, solute carrier family 1 member 7
External IDs	OMIM: 604471; MGI: 2444087; HomoloGene: 21327; GeneCards: SLC1A7; OMA:SLC1A7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 53,087,179 bp[1] End 53,142,638 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 107,825,529 bp[2] End 107,870,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa granulocyte jejunal mucosa right ovary gallbladder tibial nerve left ovary testicle right coronary artery left uterine tube Top expressed in neural layer of retina epithelium of lens outer nuclear layer retinal pigment epithelium inner nuclear layer left lobe of liver spermatid skin of abdomen pituitary gland testicle More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity L-glutamate transmembrane transporter activity amino acid transmembrane transporter activity high-affinity glutamate transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane presynapse Biological process glutamate secretion ion transport dicarboxylic acid transport transmembrane transport amino acid transmembrane transport L-glutamate transmembrane transport neurotransmitter uptake neurotransmitter reuptake Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6512 242607 Ensembl ENSG00000162383 ENSMUSG00000008932 UniProt O00341 Q8JZR4 RefSeq (mRNA) NM_001287595 NM_001287596 NM_001287597 NM_006671 NM_146255 RefSeq (protein) NP_001274524 NP_001274525 NP_001274526 NP_006662 NP_666367 Location (UCSC) Chr 1: 53.09 – 53.14 Mb Chr 4: 107.83 – 107.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000162383 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008932 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 1 (glutamate transporter)".
6. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. Bibcode:1997PNAS...94.4155A. doi:10.1073/pnas.94.8.4155. PMC 20584. PMID 9108121.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
• Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.