Cranioschisis (Greek: κρανιον kranion, "skull", and σχίσις schisis, "split") is a skull-related neural tube defect. The skull does not close all the way in this deformity (especially at the occipital region). As a result, the amniotic fluid enters the brain, leading to eventual brain degeneration and anencephaly.[1] Craniorachischisis is on the extreme end of the dysraphism spectrum, wherein the entire length of the neural tube fails to close.[2]
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